AI Article Synopsis
- Mixed pancreatic tumors that combine epithelial and mesenchymal components are rare and often invasive.
- A unique case of a 72-year-old woman revealed a sarcomatous change in a residual intraductal papillary mucinous neoplasm (IPMN) without any invasive features.
- Both tumor types in the case exhibited abnormal p53 protein expression and shared a specific mutation in the KRAS gene, with no signs of relapse after 6 months.*
Article Abstract
Mixed pancreatic epithelial and mesenchymal tumors are rare, usually invasive, entities. Intraductal papillary mucinous neoplasm (IPMN) is a precursor of invasive ductal carcinoma and shares mutations with its invasive counterparts. We report the case of a 72-year-old female with a previously undescribed sarcomatous transformation of a residual IPMN with no evidence of an invasive component. The mesenchymal component showed no heterologous differentiation. Both the epithelial and the mesenchymal populations showed aberrant expression of p53 protein and the same point mutation in KRAS gene. After a 6 month follow up, there were no signs of local or distant relapse. The present case suggests that sarcomatous transformation is possible in non-invasive, intraductal pancreatic lesions.
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| http://dx.doi.org/10.1016/j.patol.2021.05.004 | DOI Listing |
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