AI Article Synopsis
- The outflow tract of the heart is formed through a specific process involving progenitor cells from the second heart field, which must proliferate and position correctly to create the necessary heart structure.
- Disruption during this development can lead to serious heart defects, particularly in how the outflow tract rotates and separates.
- Recent findings show that Fibroblast Growth Factor 8 (FGF8) not only promotes cell survival and growth but also shapes how heart muscle cells develop, ensuring they don't incorrectly adopt the characteristics of functioning heart muscle too early.
Article Abstract
Development of the outflow tract of the heart requires specification, proliferation and deployment of a progenitor cell population from the second heart field to generate the myocardium at the arterial pole of the heart. Disruption of these processes leads to lethal defects in rotation and septation of the outflow tract. We previously showed that Fibroblast Growth Factor 8 (FGF8) directs a signaling cascade in the second heart field that regulates critical aspects of OFT morphogenesis. Here we show that in addition to the survival and proliferation cues previously described, FGF8 provides instructive and patterning information to OFT myocardial cells and their progenitors that prevents their aberrant differentiation along a working myocardial program.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686765 | PMC |
| http://dx.doi.org/10.1016/j.ydbio.2023.04.001 | DOI Listing |
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