In the context of the Western European Acheulean Project, this study aims to characterize Acheulean technology in Western Europe through the analysis of handaxes and cleavers from 10 key sites (Britain 4, France 4, and Spain 2) to acquire a regional view of the occupation. The historically different systems used to categorize and analyze the data have made it difficult to compare results. Here we apply a unified and simple method (Western European Acheulean Project) that combines the traditional technological and metrical analysis of assemblages containing handaxes and cleavers with an in-depth geometric morphometric approach using three-dimensional models. This approach allows us to achieve a regional interpretation that identifies innovations through time and shaping strategies across the area. Our findings indicate the existence of two main technological groups in the sampled record: 1) northwestern and central France and Britain, from MIS 17/16 to MIS 11, and 2) Atlantic edge (Atapuerca in Spain and Menez-Dregan in France), from MIS 12/11 to MIS 8. Based on our technological analysis, the shaping of handaxes and cleavers was developed through time as a continuum of accumulative actions, with longer and more complex shaping strategies over time. Shaping technology shows traditions of manufacture over both time and geographical areas, which suggest cultural diffusion. Our geometric morphometric analysis further helped to identify not only general trends but also local adaptations in handaxe forms. Based on our findings, there were no apparent sudden innovations, but rather the application and development of specific techniques to refine size and shape.
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http://dx.doi.org/10.1016/j.jhevol.2023.103357 | DOI Listing |
PNAS Nexus
January 2025
Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Here, we present Link-Seq, a highly efficient droplet microfluidic method for combined sequencing of antibody-encoding genes and the transcriptome of individual B cells at large scale. The method is based on 3' barcoding of the transcriptome and subsequent single-molecule PCR in droplets, which freely shift the barcode along specific gene regions, such as the antibody heavy- and light-chain genes. Using the immune repertoire of COVID-19 patients and healthy donors as a model system, we obtain up to 91.
View Article and Find Full Text PDFData Brief
February 2025
Marine Research Institute, Klaipėda University, H. Manto 84, 92294 Klaipėda, Lithuania.
Over the last few decades, climate change in Svalbard (European Arctic) has led to the emergence and growth of periglacial coastal lagoons in the place of retreating glaciers. In these emerging water bodies, new ecosystems are formed, consisting of elements presumably entering the lagoon from the melting glacier, the surrounding tundra water bodies and the coastal ocean. The data presented here were collected from an emerging lagoon in the western region of Spitsbergen, Svalbard, situated between the retreating Eidembreen Glacier and Eidembukta Bay in 2022-2023.
View Article and Find Full Text PDFCommun Psychol
January 2025
School of Psychological Science, University of Bristol, Bristol, UK.
The generation and distribution of hyper-partisan content on social media has gained millions of exposure across platforms, often allowing malevolent actors to influence and disrupt democracies. The spread of this content is facilitated by real users' engaging with it on platforms. The current study tests the efficacy of an 'inoculation' intervention via six online survey-based experiments in the UK and US.
View Article and Find Full Text PDFRev Esp Anestesiol Reanim (Engl Ed)
January 2025
Retired.
Aims: The prevalence of burnout syndrome dimensions in anesthesiologists show notable international differences. In this study, mean prevalences of European and North American anesthesiologists are compared.
Methods: Quantitative systematic review (meta-analysis) following the PRISMA and MOOSE criteria.
Lancet Neurol
February 2025
Department of Cardiology, University Hospital Leipzig, Leipzig, Germany; Clinic for Cardiology and Pneumology, University Medicine Göttingen, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Göttingen, Germany.
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