AKT activity orchestrates marginal zone B cell development in mice and humans.

Cell Rep

Institut Necker Enfants Malades, INSERM U1151-CNRS UMR 8253, 156-160, rue de Vaugirard, 75015 Paris, France; Université de Paris Cité, Paris Descartes, Faculté de Médecine, Paris, France; AP-HP, Hôpital Necker Enfants Malades, Paris, France. Electronic address:

Published: April 2023

The signals controlling marginal zone (MZ) and follicular (FO) B cell development remain incompletely understood. Here, we show that AKT orchestrates MZ B cell formation in mice and humans. Genetic models that increase AKT signaling in B cells or abolish its impact on FoxO transcription factors highlight the AKT-FoxO axis as an on-off switch for MZ B cell formation in mice. In humans, splenic immunoglobulin (Ig) DCD27 B cells, proposed as an MZ B cell equivalent, display higher AKT signaling than naive IgDCD27 and memory IgDCD27 B cells and develop in an AKT-dependent manner from their precursors in vitro, underlining the conservation of this developmental pathway. Consistently, CD148 is identified as a receptor indicative of the level of AKT signaling in B cells, expressed at a higher level in MZ B cells than FO B cells in mice as well as humans.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2023.112378DOI Listing

Publication Analysis

Top Keywords

mice humans
12
akt signaling
12
marginal zone
8
cell development
8
cell formation
8
formation mice
8
signaling cells
8
cells
6
akt
5
cell
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!