AI Article Synopsis
- Heart transplantation is the best treatment for severe heart failure but faces a donor shortage, leading to interest in regenerative medicine using human pluripotent stem cells (hPSCs).
- Key challenges in using hPSCs include scaling up production, ensuring safety against tumor formation, and developing effective transplantation strategies.
- Despite potential issues like arrhythmia and immune rejection, advancements in hPSC research could transform treatment options for severe heart failure patients through cell therapy.
Article Abstract
Heart transplantation (HT) is the only definitive treatment available for patients with end-stage heart failure who are refractory to medical and device therapies. However, HT as a therapeutic option, is limited by a significant shortage of donors. To overcome this shortage, regenerative medicine using human pluripotent stem cells (hPSCs), such as human embryonic stem cells and human-induced pluripotent stem cells (hiPSCs), has been considered an alternative to HT. Several issues, including the methods of large-scale culture and production of hPSCs and cardiomyocytes, the prevention of tumorigenesis secondary to contamination of undifferentiated stem cells and non-cardiomyocytes, and the establishment of an effective transplantation strategy in large-animal models, need to be addressed to fulfill this unmet need. Although post-transplantation arrhythmia and immune rejection remain problems, the ongoing rapid technological advances in hPSC research have been directed toward the clinical application of this technology. Cell therapy using hPSC-derived cardiomyocytes is expected to serve as an integral component of realistic medicine in the near future and is being potentially viewed as a treatment that would revolutionize the management of patients with severe heart failure.
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| http://dx.doi.org/10.1016/j.cardfail.2022.10.433 | DOI Listing |
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