AI Article Synopsis
- A study tested the effects of 1 alpha, 24(R)-dihydroxyvitamin D3 (1,24(OH)2D3) on calcium (Ca) metabolism in vitamin D-replete rats to evaluate its potential for treating osteoporosis.
- Rats injected with varying doses of 1,24(OH)2D3 showed increased intestinal Ca absorption and urinary excretion, along with higher bone resorption but no change in bone formation.
- Overall, the findings suggest that 1,24(OH)2D3 does not significantly improve whole-body calcium retention and may not be effective for osteoporosis treatment.
Article Abstract
It has been suggested that 1 alpha, 24(R)-dihydroxyvitamin D3 (1,24(OH)2D3), a chemically synthesized vitamin D analogue, may have the property to enhance whole-body Ca retention and may thus be of use in osteoporosis. In order to test this hypothesis the main fluxes of Ca metabolism were measured in vitamin D-replete rats injected ip with 1.24(OH)2D3 at daily doses of 25, 50 and 100 pmol for 10 days. As compared with pair fed control animals, rats treated with 1,24(OH)2D3 displayed a significant rise in net intestinal absorption of Ca and in urinary excretion of Ca, and increase in bone resorption but no significant change in bone formation. Whole body Ca retention was not changed at 25 pmol/day and showed a trend to decrease at 50 and 100 pmol/day. In conclusion these results do not suggest that among available vitamin D analogues, 1,24(OH)2D3 would be particularly useful for increasing bone Ca retention in osteoporosis.
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| http://dx.doi.org/10.1530/acta.0.1110572 | DOI Listing |
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