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Therapeutic extraction of second molars in orthodontics: a scoping review.
BMC Oral Health
January 2025
Department of Orthodontics, Faculty of Dentistry, Mansoura University, Mansoura, 35516, Egypt.
Objective: To review the literature to identify the present evidence on the extraction of second molars in orthodontics.
Materials & Method: A search of the MEDLINE/PubMed, Scopus, Web of Science™, and ProQuest databases for full-text articles was done on March 5, 2024. The search went back till the 1st of January 1991 and was limited to articles in English.
Ferroptosis and PANoptosis Under Hypoxia Pivoting on the Crosstalk between DHODH and GPX4 in Corneal Epithelium.
Free Radic Biol Med
January 2025
Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:
Cell death under stress conditions like hypoxia, involves multiple interconnected pathways. In this study, a stable dihydroorotate dehydrogenase (DHODH) knockdown human corneal epithelial cell line was established to explore the regulation of hypoxic cell death, which was mitigated by various cell death inhibitors, particularly by a lipid peroxyl radical scavenger liproxstatin-1 (Lip-1), suggesting that hypoxic cell death involves crosstalk of ferroptosis and PANoptosis. We discovered that both DHODH and Glutathione peroxidase 4 (GPX4) protected cells from hypoxic death by inhibiting lipid peroxidation, mitochondrial reactive oxygen species (ROS) and maintaining mitochondrial membrane potential.
View Article and Find Full Text PDFTransforming literature screening: The emerging role of large language models in systematic reviews.
Proc Natl Acad Sci U S A
January 2025
Department of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
Systematic reviews (SR) synthesize evidence-based medical literature, but they involve labor-intensive manual article screening. Large language models (LLMs) can select relevant literature, but their quality and efficacy are still being determined compared to humans. We evaluated the overlap between title- and abstract-based selected articles of 18 different LLMs and human-selected articles for three SR.
View Article and Find Full Text PDF[The multimorbid patient-Risk stratification and indications in pancreatic surgery].
Chirurgie (Heidelb)
January 2025
Klinik und Poliklinik für Viszeral‑, Thorax- und Gefäßchirurgie, Universitätsklinikum und Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Deutschland.
Background: Pancreatic surgery is still associated with significant morbidity. In a simultaneously increasingly ageing population with elevated morbidity, the risk stratification and indications for surgery are of particular importance.
Objective: Assessment of the impact of multimorbidity of patients on the postoperative outcome after pancreatic surgery.
[Positional plagiocephaly and neurodevelopment: a narrative review].
Andes Pediatr
October 2024
Clínica Plagiocefalia Argentina, Buenos Aires, Argentina.
Unlabelled: Positional plagiocephaly is a common pediatric pathology that has been considered as a cosmetic condition, but recently its association with neurodevelopmental delay has been explored.
Objective: To perform a narrative review updating the findings of a 2017 systematic review on plagiocephaly and neurodevelopment.
Methodology: Articles in the MEDLINE, PubMed, Google Scholar, and DeepDyve databases were reviewed, data were extracted from the most relevant studies evaluating their methodological quality.
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