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A new concept for the treatment of atopic dermatitis: silver-nanolipid complex (sNLC).
Int J Pharm
February 2014
Freie Universität Berlin, Institut für Pharmazie, Department of Pharmaceutics, Biopharmaceutics and Nutricosmetics, Berlin, Germany.
In the treatment of mild to medium severe atopic dermatitis a new formulation proved to be highly efficient. The formulation is based on a combination of microsilver and nanolipid carriers (NLC) incorporated into an o/w cream and a lotion. A theory of action was proposed, the formation of silver-NLC complex (sNLC).
View Article and Find Full Text PDFStudies on the pharmacokinetics and metabolism of prednicarbate after cutaneous and oral administration.
Skin Pharmacol
February 1994
Medizinische Klinik Bergmannsheil, Bochum, FRG.
Prednicarbate (PC) is a nonhalogenated derivative of prednisolone which is used for the local treatment of corticoid-sensitive skin diseases. In this study, the pharmacokinetics and the metabolism of PC in humans are investigated after cutaneous ointment application (75 mg PC) and after systemic oral administration (40 mg PC) in 8 healthy volunteers. In addition, the possible suppression of endogenous cortisol secretion by both application forms was monitored.
View Article and Find Full Text PDFWe report on the clinical efficacy of the local corticoid prednicarbate (chemical name: prednisolone-17-ethyl carbonate-21-propionate). In a concentration of 0.25%, it can be assigned to corticoid force class III.
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