Introduction: Transient bone marrow edema (TBME) is a condition that typically presents in middle-aged adults with a male to female ratio of 3:1. Cases have also been noted in females during the third trimester of pregnancy. Vitamin D deficiency has been linked to this condition as the pathophysiology demonstrates poorly mineralized osteoid in presenting lesions. It is rare for a healthy child or adolescent to present with TBME introducing the purpose of this case study. This case report aims to provide medical and surgical education on TBME in a young and healthy adolescent. To our best knowledge, this is the first report on the use of subchondroplasty to treat transient bone marrow of the navicular in an adolescent male.
Case Report: A 16-year-old adolescent male with foot and ankle pain is treated from September of 2017 to September of 2019. The patient failed initial conservative treatments. His treatment concluded with subchondroplasty of the navicular bone, typically contraindicated due to the risk of avascular necrosis (AVN). The patient received follow-up in March of 2020, which included additional magnetic resonance imaging (MRI) for long-term treatment outcome data.
Conclusion: The patient was successfully treated with subchondroplasty after conservative therapy failed. In patients with TBME, subchondroplasty may not be the best option due to risk of AVN. At 1-year follow-up, our patient was asymptomatic and MRI showed reduction in edema.
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http://dx.doi.org/10.13107/jocr.2022.v12.i12.3482 | DOI Listing |
Bone Joint Res
January 2025
Department of Mechanical Engineering & Mechanics, Lehigh University, Bethlehem, Pennsylvania, USA.
Aims: The "2 to 10% strain rule" for fracture healing has been widely interpreted to mean that interfragmentary strain greater than 10% predisposes a fracture to nonunion. This interpretation focuses on the gap-closing strain (axial micromotion divided by gap size), ignoring the region around the gap where osteogenesis typically initiates. The aim of this study was to measure gap-closing and 3D interfragmentary strains in plated ovine osteotomies and associate local strain conditions with callus mineralization.
View Article and Find Full Text PDFPeriodontol 2000
December 2024
Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Periodontitis arises from imbalanced host-microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro-inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment. There is no consensus on the factors that lead to a conversion from gingivitis to periodontitis, but one possibility is the proximity of the inflammation to the bone, which promotes bone resorption and inhibits subsequent bone formation during coupled bone formation.
View Article and Find Full Text PDFImmunohematology
December 2024
International Blood Group Reference Laboratory, NHS Blood and Transplant, Bristol, UK.
A previously healthy 32-year-old male patient was admitted to hospital with malaise, dyspnea, anemia, thrombocytopenia, and leukopenia. Anemia and thrombocytopenia worsened during the third week. Considering the possible need for transfusion, routine ABO and D typing and an antibody detection test were performed.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
National Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing 100094, China.
TMEM16A, a key calcium-activated chloride channel, is crucial for many physiological and pathological processes such as cancer, hypertension, and osteoporosis, etc. However, the regulatory mechanism of TMEM16A is poorly understood, limiting the discovery of effective modulators. Here, we unveil an allosteric gating mechanism by presenting a high-resolution cryo-EM structure of TMEM16A in complex with a channel inhibitor that we identified, Tamsulosin, which is resolved at 2.
View Article and Find Full Text PDFWorld J Stem Cells
December 2024
Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura 247-8533, Kanagawa, Japan.
Background: To date, no specific treatment has been established to reverse progressive chronic kidney disease (CKD).
Aim: To evaluate the safety and efficacy of autologous CD34 cell transplantation in CKD patients who exhibited a progressive decline in renal function.
Methods: The estimated glomerular filtration rate (eGFR) at the beginning of the study was 15.
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