AI Article Synopsis
- GORD is becoming more common in the western world and can lead to serious health issues like esophagitis and cancer, as well as negatively affect quality of life.
- Current treatments include lifestyle changes, medications, and surgery, with new minimally invasive endoscopic therapies (ARET) emerging as potential alternatives.
- Effective patient selection based on a deep understanding of ARET options is essential for positive outcomes, and further research is needed to clarify the future role of these therapies.
Article Abstract
The prevalence of the gastro-oesophageal reflux disease (GORD) in the western world is increasing. Uncontrolled GORD can lead to harmful long-term sequela such as oesophagitis, stricture formation, Barrett's oesophagus and oesophageal adenocarcinoma. Moreover, GORD has been shown to negatively impact quality of life. The current treatment paradigm for GORD consists of lifestyle modification, pharmacological control of gastric acid secretion or antireflux surgery. In recent years, several minimally invasive antireflux endoscopic therapies (ARET) have been developed which may play a role in bridging the unmet therapeutic gap between the medical and surgical treatment options. To ensure optimal patient outcomes following ARET, considered patient selection is crucial, which requires a mechanistic understanding of individual ARET options. Here, we will discuss the differences between ARETs along with an overview of the current evidence base. We also outline future research priorities that will help refine the future role of ARET.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086720 | PMC |
| http://dx.doi.org/10.1136/flgastro-2022-102343 | DOI Listing |
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