AI Article Synopsis
- CAFs are altered by cancer cells to support tumor growth, specifically in esophageal cancer.
- Chen et al. identify a process where premalignant esophageal epithelial cells transform normal fibroblasts into CAFs.
- This transformation involves the downregulation of a specific signaling pathway, ANXA1-FRP2.
Article Abstract
Cancer-associated fibroblasts (CAFs) are recruited and rewired by cancer cells to become protumorigenic. The molecular mechanisms underlying this crosstalk in esophageal cancer are completely unknown. Chen et al. discover that premalignant epithelial cells of the esophagus rewire normal resident fibroblasts into CAFs through the downregulation of ANXA1-FRP2 signaling.
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| http://dx.doi.org/10.1016/j.ccell.2023.03.020 | DOI Listing |
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