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Molecular and metabolomic characterization of hiPSC-derived cardiac fibroblasts transitioning to myofibroblasts.
Front Cell Dev Biol
December 2024
Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Background: Mechanical stress and pathological signaling trigger the activation of fibroblasts to myofibroblasts, which impacts extracellular matrix composition, disrupts normal wound healing, and can generate deleterious fibrosis. Myocardial fibrosis independently promotes cardiac arrhythmias, sudden cardiac arrest, and contributes to the severity of heart failure. Fibrosis can also alter cell-to-cell communication and increase myocardial stiffness which eventually may lead to lusitropic and inotropic cardiac dysfunction.
View Article and Find Full Text PDFValidation of ACR TI-RADS performance in transition age: results from a multicenter retrospective study by the TALENT study group.
Endocrine
December 2024
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Purpose: Although thyroid nodules are less common in the pediatric population, the risk of malignancy is higher than in adult patients. The aim of this study was to evaluate the ultrasonographic predictive factors of malignancy in thyroid nodules and to validate American College of Radiologists (ACR) TI-RADS performance in transition age patients.
Methods: One hundred forty-two patients aged between 14 and 21 years referred to the participating centers for FNA biopsy of a thyroid nodule between 2007 and 2022 were included and ultrasound reports and sonographic images were retrospectively analyzed.
Electrospun composite membranes of ethyl cellulose and MXene (TiCT): Biocompatible platforms for enhanced drug delivery and antibacterial wound healing.
Int J Biol Macromol
December 2024
Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand; Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand; Center of Excellence in Materials Science and Technology, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address:
Ethyl cellulose (EC), a degradable cellulose derivative, served as a primary component in membranes fabricated by electrospinning for in vitro drug delivery applications. An effective strategy to enhance drug release was incorporating high-surface-area nanomaterials into polymeric drug carriers, which facilitated drug attachment to both the polymer matrix and additive surfaces, promoting release. MXene (TiCT) demonstrated promising potential in improving tensile mechanical properties, antibacterial activity, and curcumin (Cur) release performance of EC membrane.
View Article and Find Full Text PDFSea food by-products valorization for biomedical applications: evaluation of their wound regeneration capabilities in an skin model.
Front Vet Sci
November 2024
Department of Comparative Biomedicine and Food Science, University of Padua, Padua, Italy.
Introduction: The skin is often exposed to harmful stimuli that might compromise its integrity and functionality. After an injury, the skin has a limited capability to restore its complex structure, and in the case of severe skin damage, surgical operations and rapid application of wound dressings are often required to promote optimal wound healing. Nowadays, collagen-based biomaterials are widely used in combination with bioactive molecules able to prevent excessive inflammation and possible infections.
View Article and Find Full Text PDFBuilding competency to deal with environmental health challenges: experiences and a proposal.
Front Public Health
December 2024
International Society Doctors for the Environment (ISDE), Rete Italiana Medici Sentinella per l'Ambiente (RIMSA), Arezzo, Italy.
The global landscape of professional training in environmental health, encompassing ecological public health or environmental public health, lacks consistent global implementation for training programs for public health practitioners, clinical professionals, and individuals across various disciplines, as well as standardized curricula for undergraduates. This training gap is related to the overall lack of capacity in addressing the population impacts of the triple challenge of pollution, biodiversity loss, and climate change, impeding the worldwide transition to and development of ecological sustainability. This paper reviews existing approaches and their potential to address implementation challenges within the necessarily tight timescale.
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