Background: Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Opportunistic colonoscopy may be beneficial in reducing the incidence of CRC by detecting its precursors.
Aim: To determine the risk of colorectal adenomas in a population who underwent opportunistic colonoscopy, and demonstrate the need for opportunistic colonoscopy.
Methods: A questionnaire was distributed to patients who underwent colonoscopy in the First Affiliated Hospital of Zhejiang Chinese Medical University from December 2021 to January 2022. The patients were divided into two groups, the opportunistic colonoscopy group who underwent a health examination including colonoscopy without intestinal symptoms due to other diseases, and the non-opportunistic group. The risk of adenomas and influence factors were analyzed.
Results: Patients who underwent opportunistic colonoscopy had a similar risk to the non-opportunistic group, in terms of overall polyps (40.8% vs. 40.5%, P = 0.919), adenomas (25.8% vs. 27.6%, P = 0.581), advanced adenomas (8.7% vs. 8.6%, P = 0.902) and CRC (0.6% vs. 1.2%, P = 0.473). Patients with colorectal polyps and adenomas in the opportunistic colonoscopy group were younger (P = 0.004). There was no difference in the detection rate of polyps between patients who underwent colonoscopy as part of a health examination and those who underwent colonoscopy for other reasons. In patients with intestinal symptoms, abnormal intestinal motility and changes in stool characteristics were frequent (P = 0.014).
Conclusion: The risk of overall colonic polyps, advanced adenomas in healthy people undergoing opportunistic colonoscopy no less than that in the patients with intestinal symptoms, positive FOBT, abnormal tumor markers, and who accepted re-colonoscopy after polypectomy. Our study indicates that more attention should be paid to the population without intestinal symptoms, especially smokers and those older than 40 years.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101387 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0283575 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Effectiveness of Colonoscopy in Reducing Incidence of Late-stage Colorectal Cancer Within an Opportunistic Screening Program.
Surg Laparosc Endosc Percutan Tech
December 2024
Department of Surgery, Division of Colorectal Surgery, Hospital Alemán.
Background: The effectiveness of colonoscopy in preventing colorectal cancer (CRC) within opportunistic screening programs has not been clearly established. The aim of this study was to analyze the effectiveness of colonoscopy within an opportunistic screening program using nested case-control study.
Methods: Subjects who received a diagnosis of CRC (CG) between the ages of 50 and 90 years were included and matched by age and gender in a 1:5 ratio with patients without CRC diagnosis (COG) during the period 2015 to 2023.
Amoebic colitis in a 39-year-old man with HIV.
CMAJ
September 2024
Department of Infectious Diseases, Tokyo Metropolitan Toshima Hospital, Tokyo, Japan.
A novel dual-target Septin9 methylation assay for improved detection of early-stage colorectal cancer and high-grade intraepithelial neoplasia.
BMC Cancer
July 2024
USK Bioscience, Co., Ltd, 5th Floor, Building A, Guanlan High-tech Park, Shenzhen, China.
Background: Colorectal cancer (CRC) ranks as the third most common malignancies in the world, and periodic examination of the patient is advantageous in reducing the mortality of CRC. The first blood-based Septin9 gene methylation assay which recognized by the US FDA for CRC examination was Epi proColon. However, this assay was not broadly applied in the current clinical guideline because of its relatively lower sensitivity in the detection of early-stage CRC.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluates whether annual fecal immunochemical tests (FIT) are necessary for patients who recently had a total colonoscopy (TCS) in Japan, as current guidelines recommend annual FIT screening but lack consensus for these patients.
- Researchers analyzed data from 671 patients with positive FIT results, dividing them into those who had a TCS within the past 5 years and those who had not, and found that those with recent TCS had significantly lower rates of advanced neoplasia (4.6% vs. 12.1%).
- The conclusion suggests that patients with adenomatous lesions should follow their surveillance program with repeat TCS instead of annual FIT, while the necessity of annual FIT
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!