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| http://dx.doi.org/10.1001/jamanetworkopen.2023.7962 | DOI Listing |
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Multisystem clinicopathologic and genetic analysis of MELAS.
Orphanet J Rare Dis
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Department of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhongshan Road 321#, Nanjing, 210008, Jiangsu, China.
Background And Objectives: Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome is a maternally inherited mitochondrial disorder that mostly affects the central nervous system and skeletal muscle. This study provides a comprehensive summary of the clinical symptoms, multisystemic pathogenesis, and genetic characteristics of MELAS syndrome. The aim was to improve comprehension of clinical practice and gain a deeper understanding of the latest pathophysiological theories.
View Article and Find Full Text PDFIdentification and validation of ATP6V1G1-regulated phosphorylated proteins in hepatocellular carcinoma.
PLoS One
December 2024
Department of Clinical Laboratory, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education Nanning, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China.
V-ATPase Subunit G1 (ATP6V1G1) is one of the subunits of Vacuolar ATPases. Previous studies have indicated that ATP6V1G1 plays important roles in hepatocellular carcinoma (HCC) and is associated with HCC progression. However, the effect of ATP6V1G1 in HCC requires further elucidation.
View Article and Find Full Text PDFSoluble (pro)renin receptor (s(P)RR) levels in women carrying Aboriginal and/or Torres Strait Islander babies; the Gomeroi Gaaynggal study.
Pregnancy Hypertens
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School of Biomedical Sciences and Pharmacy, College of Health Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia; Women's Health Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia. Electronic address:
Objective: To determine the levels of soluble (pro)renin receptor (s(P)RR) in women carrying Aboriginal and/or Torres Strait Islander (First Nations) babies and investigate whether s(P)RR levels change in women who have complicated pregnancies.
Study Design: Cross-sectional analysis of data (2010-2018). Data/samples were from the Gomeroi Gaaynggal Study, a longitudinal cohort study based on Gomeroi/Kamilaroi lands (Tamworth), NSW, Australia.
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Eosinophilic esophagitis (EoE) is a progressive type 2 inflammatory disease characterized by symptoms related to esophageal dysfunction and significant esophageal eosinophilic infiltration. It can affect patients from infancy through adulthood. Pediatric EoE has a multidimensional impact on the quality of life of both patients and their families.
View Article and Find Full Text PDFEfficacy and safety of vonoprazan-based bismuth quadruple therapy for first-line Helicobacter pylori eradication: A large-scale, real-world study.
Medicine (Baltimore)
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Department of Gastroenterology, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China.
Article Synopsis
- Vonoprazan (VPZ) shows better acid-inhibition than proton pump inhibitors (PPIs) but little research has been done on its effectiveness in treating Helicobacter pylori infection with bismuth quadruple therapy (VBQT).* -
- This study evaluated VBQT's safety and effectiveness in eradicating H pylori in treatment-naive patients over a period from March 2021 to May 2023, involving 612 participants.* -
- Results indicated high eradication rates of 84.3% to 96.4% across various analyses, with a 12.7% adverse event rate and 96.9% treatment compliance, suggesting VBQT is a promising first-line treatment for
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