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http://dx.doi.org/10.1111/pcn.13549 | DOI Listing |
J Psychiatry Neurosci
September 2024
From the Department of Psychiatry and the McGill University Health Centre, McGill University, Montréal, Que.
For 3000 years, psychedelics have been used in religious contexts to enhance spiritual thinking, well-being, and a sense of community. In the last few years, a renaissance in the use of psychedelic drugs for mental disorders has occurred in Western society; consequently, a pressing scientific need to elucidate the intricate mechanisms underlying their actions has arisen. Psychedelics mainly bind to serotonin (5-HT) receptors, particularly 5-HT receptors, but may also bind to other receptors.
View Article and Find Full Text PDFNeuropsychopharmacology
November 2024
Laureate Institute for Brain Research, Tulsa, OK, USA.
Neuroimaging plays a crucial role in understanding brain structure and function, but the lack of transparency, reproducibility, and reliability of findings is a significant obstacle for the field. To address these challenges, there are ongoing efforts to develop reporting checklists for neuroimaging studies to improve the reporting of fundamental aspects of study design and execution. In this review, we first define what we mean by a neuroimaging reporting checklist and then discuss how a reporting checklist can be developed and implemented.
View Article and Find Full Text PDFNeuropsychopharmacology
December 2024
Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
The kappa opioid receptor (KOR) and its endogenous agonist dynorphin have been implicated in multiple psychiatric conditions including psychotic disorders. We tested the hypotheses that kappa expression is elevated and associated with psychotic symptoms in schizophrenia. We measured kappa expression in unmedicated patients with schizophrenia (7 female, 6 male) and matched controls (7 female, 6 male) with positron emission tomography (PET).
View Article and Find Full Text PDFNeuropsychopharmacology
November 2024
New York State Psychiatric Institute, New York, NY, USA.
Neuromelanin-sensitive MRI is a burgeoning non-invasive neuroimaging method with an increasing number of applications in psychiatric research. This MRI modality is sensitive to the concentration of neuromelanin, which is synthesized from intracellular catecholamines and accumulates in catecholaminergic nuclei including the dopaminergic substantia nigra and the noradrenergic locus coeruleus. Emerging data suggest the utility of neuromelanin-sensitive MRI as a proxy measure for variability in catecholamine metabolism and function, even in the absence of catecholaminergic cell loss.
View Article and Find Full Text PDFPsychiatry Clin Neurosci
July 2023
Drug Research Division, Sumitomo Pharma Co., Ltd., Osaka, Japan.
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