Background: The apolipoprotein E (ApoE) genetic variation may contribute to the development of Cerebral Infarction (CI). Serum lipid levels are known risk factors for CI, but the effect of the ApoE gene polymorphism on lipid metabolism remains unclear. This retrospective cohort study was designed to determine the role of ApoE genotypes in CI risk and the relationships between ApoE gene polymorphism and serum lipid levels among the population of northwest China.
Patients And Methods: 517 CI patients and 517 non-CI controls were enrolled in the study. Polymerase chain reaction and hybridization were utilized to determine the ApoE gene polymorphisms.
Results: The ε3/ε4 genotype and ε4 allele frequency were significantly higher in CI patients than in controls. When stratified by age and sex, statistically significant differences in the distribution and frequency of the ε3/ε4 genotype and ε4 allele were found between patients and controls. Compared to ε2 carriers, ε4 carriers had significantly lower ApoE levels and higher low-density lipoprotein cholesterol (LDL-C), ApoB and ApoB/ApoA-I levels in both two groups. Additionally, control participants with ε4 carriers had significantly higher levels of lipoprotein and total cholesterol (TC) levels than ε2 carriers, while CI patients with ε4 carriers had a significantly lower level of ApoA-I. After adjusting for other established risk factors, drinking, hypertension, lipoprotein, triglycerides (TG) and ε4 allele were significant independent risk factors for CI, which was shown to be associated with a nearly two-fold CI risk.
Conclusion: This study demonstrated that ε4 allele is independent risk factors for CI among patients in Northwest China. ApoE polymorphism was associated with CI, which was partly mediated through blood lipids and may also be mediated through non-lipid pathways. These data might be of great clinical significance in individualized preventive and therapeutic strategies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083142 | PMC |
| http://dx.doi.org/10.2147/PGPM.S404663 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Psychosocial Stress at Work and Risks for Burnout Among Hotel Workers.
J Occup Environ Med
November 2024
University of Michigan, School of Nursing, Ann Arbor, MI, USA.
Objective: Hotel workers are at risk for burnout. We tested the association between effort-reward imbalance (ERI) and burnout.
Methods: Participants were recruited through social media and completed an online survey.
Association between the occupation of pregnant women's partners and risks of infant low birth weight and preterm birth in a prospective birth cohort: the Japan Environment and Children's Study.
J Occup Environ Med
November 2024
Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan.
Objective: We examined the association between the occupations of pregnant women's partners and infant low birth weight (LBW) and preterm birth (PB).
Methods: Birth outcome data were collected from 46,540 participants enrolled in the Japan Environment and Children's Study. Participants were recruited from January 2011 to March 2014.
Metabolic Dysfunction-Associated Steatotic Liver Disease.
Ann Intern Med
January 2025
Department of Medicine, Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts (S.M.J.A., M.L.).
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease in the United States. It is characterized by steatosis in the liver and is potentially reversible. Risk factors include obesity, type 2 mellitus, and other metabolic disorders.
View Article and Find Full Text PDFBranch retinal vein occlusion and Valsalva manoeuvre in wind instrument players and singers.
Clin Exp Optom
January 2025
Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Australia.
Clinical Relevance: There are many recognised risk factors for retinal vein occlusions. It is plausible that musicians who play wind instruments or use their voice as their primary instrument may be at increased risk of branch retinal vein occlusions through repeated Valsalva manoeuvre.
Background: Repeated valsalva manoeuvres are commonly performed by musicians using high resistance wind instruments.
Assessing bioaccumulation with biomagnification factors from dietary bioaccumulation tests.
Integr Environ Assess Manag
January 2025
ExxonMobil Petroleum and Chemical BV, Machelen, Belgium.
Despite the fact that the UN Stockholm Convention on persistent organic pollutants specifically acknowledges that Arctic ecosystems and Indigenous communities are particularly at risk due to biomagnification of contaminants in traditional foods, the bioconcentration factor (BCF) of substances in fish remains the preferred metric for identifying the biomagnification potential of organic substances. The BCF measures uptake of substances from water in water-breathing organisms, but not biomagnification of contaminants from food sources. The purpose of this study is to investigate how the biomagnification factor (BMF) can be used in bioaccumulation assessments.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!