AI Article Synopsis
- * Current treatments often use cytokines for promoting fracture healing, but they can trigger immune responses and are costly, resulting in less effective clinical outcomes.
- * New research is focusing on tissue-induced biomaterials that promote bone regeneration through optimized scaffold structures, potentially improving tissue-engineered bones without the need for expensive cytokine additions.
Article Abstract
The number of patients with bone defects caused by various bone diseases is increasing yearly in the aging population, and people are paying increasing attention to bone tissue engineering research. Currently, the application of bone tissue engineering mainly focuses on promoting fracture healing by carrying cytokines. However, cytokines implanted into the body easily cause an immune response, and the cost is high; therefore, the clinical treatment effect is not outstanding. In recent years, some scholars have proposed the concept of tissue-induced biomaterials that can induce bone regeneration through a scaffold structure without adding cytokines. By optimizing the scaffold structure, the performance of tissue-engineered bone scaffolds is improved and the osteogenesis effect is promoted, which provides ideas for the design and improvement of tissue-engineered bones in the future. In this study, the current understanding of the bone tissue structure is summarized through the discussion of current bone tissue engineering, and the current research on micro-nano bionic structure scaffolds and their osteogenesis mechanism is analyzed and discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083331 | PMC |
| http://dx.doi.org/10.3389/fbioe.2023.1127162 | DOI Listing |
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