Memory isolation is an essential technology for safeguarding the resources of lightweight embedded systems. This technique isolates system resources by constraining the scope of the processor's accessible memory into distinct units known as domains. Despite the security offered by this approach, the Memory Protection Unit (MPU), the most common memory isolation method provided in most lightweight systems, incurs overheads during domain switching due to the privilege level intervention. However, as IoT environments become increasingly interconnected and more resources become required for protection, the significant overhead associated with domain switching under this constraint is expected to be crucial, making it harder to operate with more granular domains. To mitigate these issues, we propose DEMIX, which supports efficient memory isolation for multiple domains. DEMIX comprises two mainelements- and -with the primary idea of enabling granular access control for memory by validating the domain state of the processor and the executed instructions. By achieving fine-grained validation of memory regions, our technique safely extends the supported domain capabilities of existing technologies while eliminating the overhead associated with switching between domains. Our implementation of eight user domains shows that our approach yields a hardware overhead of a slight 8% in Ibex Core, a very lightweight RISC-V processor.
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http://dx.doi.org/10.3390/s23073568 | DOI Listing |
J Immunol Methods
January 2025
Research & Development Department, Cellular Technology Limited, Shaker Heights, OH 44122, USA. Electronic address:
Owing to their ability to reliably detect even very rare antigen-specific B cells in cellular isolates such as peripheral blood mononuclear cells (PBMC), and doing so robustly in a high throughput-compatible manner, B cell ELISPOT/FluoroSpot (collectively "B cell ImmunoSpot") tests have become increasingly attractive for immune monitoring in regulated settings. Presently, there are no guidelines for the qualification and validation of B cell ImmunoSpot assay results. Here, we propose such guidelines, building on the experience acquired from T cell ImmunoSpot testing in an environment adhering to the requirements of regulatory bodies yet taking the unique features of B cell assays into account.
View Article and Find Full Text PDFAntiviral Res
January 2025
Institute of Human Virology, Zhongshan School of Medicine, and Key Laboratory of Tropical Disease Control of Ministry of Education, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:
The Omicron BA.2.86 subvariants, JN.
View Article and Find Full Text PDFObjective: To explore the lived experiences and extent of cognitive symptoms in Long COVID (LC) in a UK-based sample.
Design: This study implemented a mixed-methods design. Eight focus groups were conducted to collect qualitative data, and the Framework Analysis was used to reveal the experiences and impact of cognitive symptoms.
Biomedicines
December 2024
Department of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary.
Background: N-methyl-D-aspartate type glutamate receptors (NMDARs) are fundamental to neuronal physiology and pathophysiology. The prefrontal cortex (PFC), a key region for cognitive function, is heavily implicated in neuropsychiatric disorders, positioning the modulation of its glutamatergic neurotransmission as a promising therapeutic target. Our recently published findings indicate that AT receptor activation enhances NMDAR activity in layer V pyramidal neurons of the rat PFC.
View Article and Find Full Text PDFBackground: Intensive care unit (ICU) admissions can be traumatic for critically ill, ventilated acute respiratory distress syndrome (ARDS) patients due to fear of death, an inability to verbally communicate, reliance on health care professionals, and invasive medical interventions. Adult ARDS patients hospitalized during the COVID-19 pandemic were strictly isolated and had limited to no visitation from loved ones, impacting their access to support systems.
Objective: To explore the memories and sensory triggers for them (if applicable) of adult ARDS survivors hospitalized during the COVID-19 pandemic.
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