This paper presents a novel analog front-end for EMG sensor signal processing powered by 1 V. Such a low supply voltage requires specific design steps enabled using the 28 nm fully depleted silicon on insulator (FDSOI) technology from STMicroelectronics. An active ground circuit is implemented to keep the input common-mode voltage close to the analog ground and to minimize external interference. The amplifier circuit comprises an input instrumentation amplifier (INA) and a programmable-gain amplifier (PGA). Both are implemented in a fully differential topology. The actual performance of the circuit is analyzed using the corner and Monte Carlo analyses that comprise fifth-hundred samples for the global and local process variations. The proposed circuit achieves a high common-mode rejection ratio () of 105.5 dB and a high input impedance of 11 GΩ with a chip area of 0.09 mm2.
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http://dx.doi.org/10.3390/s23073422 | DOI Listing |
Discov Oncol
January 2025
Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine, No. 58, Yuelu District, Changsha, 410006, Hunan, China.
Objective: Rosmarinic acid (RosA) is a natural polyphenol compound that has been shown to be effective in the treatment of inflammatory disease and a variety of malignant tumors. However, its specific mechanism for the treatment of lung adenocarcinoma (LUAD) has not been fully elucidated. Therefore, this study aims to clarify the mechanism of RosA in the treatment of LUAD by integrating bioinformatics, network pharmacology and in vivo experiments, and to explore the potential of the active ingredients of traditional Chinese medicine in treating LUAD.
View Article and Find Full Text PDFJ Educ Health Promot
November 2024
College of Nursing, University of Tennessee, Knoxville, TN, USA.
Background: Diabetes burnout represents a unique experience that shares some similarities with other psychological concepts. Differentiating diabetes burnout from depression symptoms is a challenging issue. This study aims to examine diabetes burnout profiles and their association with depression.
View Article and Find Full Text PDFBioact Mater
April 2025
3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Rua Ave 1, Edifício 1 (Sede), 4805-694 Barco, Guimarães, Portugal.
Cell sheet (CS)-based approaches hold significant potential for tissue regeneration, relying on the extracellular matrix (ECM) for success. Like in native tissues, the ECM provides structural and biochemical support for cellular homeostasis and function. Effective preservation strategies that maintain ECM integrity are critical to enhance the therapeutic potential of CS-based approaches.
View Article and Find Full Text PDFBMC Plant Biol
January 2025
Research Institute of Biology and Agriculture, School of Chemistry and Biological Engineering, Shunde Innovation School, Zhongzhi International Institute of Agricultural Biosciences, University of Science and Technology Beijing, Beijing, 100083, China.
Background: Anthocyanin is an important class of water-soluble pigments that are widely distributed in various tissues of plants, and it not only facilitates diverse color changes but also plays important roles in various biological processes. Maize silk, serving as an important reproductive organ and displaying a diverse range of colors, plays an indispensable role in biotic resistance through its possession of anthocyanin. However, the copy numbers, characteristics, and expression patterns of genes involved in maize anthocyanin biosynthesis are not fully understood.
View Article and Find Full Text PDFSci Rep
January 2025
Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany.
Community-acquired pneumonia (CAP) has a significant impact on public health, especially in light of the recent SARS-CoV-2 pandemic. To enhance disease characterization and improve understanding of the underlying mechanisms, a comprehensive analysis of the plasma lipidome, metabolome and proteome was conducted in patients with viral and bacterial CAP infections, including those induced by SARS-CoV-2. Lipidomic, metabolomic and proteomic profiling were conducted on plasma samples of 69 patients suffering either from viral or bacterial CAP.
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