The @Ag core/shell electrospun fiber membrane was prepared by coaxial electrospinning combined with the UV reduction method (254 nm). The prepared @Ag core/shell nanofiber membrane has a three-dimensional structure, and its swelling ratio could reach as high as 199.87%. Traditional Chinese medicine can reduce inflammation, and the silver nanoparticles have antibacterial effects, which synergistically promote rapid wound healing. The developed @Ag core/shell nanofiber membrane can effectively inhibit the growth of the Gram-negative bacteria and the Gram-positive bacteria . The wound healing experiments in Sprague Dawley mice showed that the wound residual area rate of the @Ag core/shell electrospun nanofiber membrane group was only 1.52% on day 9, and the wound of this group basically healed on day 12, while the wound residual area rate of the gauze treatment group (control group) was 16.3% and 10.80% on day 9 and day 12, respectively. The wound of the @Ag core/shell electrospun nanofiber membrane group healed faster, which contributed to the application of the nanofiber as Chinese medicine rapid wound healing dressings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096071 | PMC |
| http://dx.doi.org/10.3390/molecules28072972 | DOI Listing |
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