(balloon flower), used as a food reserve as well as in traditional herbal medicine, is known for its multiple beneficial effects. In particular, this plant is widely used as a vegetable in Republic of Korea. We examined the ameliorative effects of on alloxan-induced pancreatic islet damage in zebrafish. The aerial part treatment led to a significant recovery in pancreatic islet size and glucose uptake. The efficacy of the aerial part was more potent than that of the root. Eight flavonoids (-) were isolated from the aerial part. Structures of two new flavone glycosides, designated dorajiside I () and II (), were elucidated to be luteolin 7--α-L-rhamno-pyranosyl (1 → 2)-(6--acetyl)-β-D-glucopyranoside and apigenin 7--α-L-rhamnopyranosyl (1 → 2)-(6--acetyl)-β-D-glucopyranoside, respectively, by spectroscopic analysis. Compounds , , and - yielded the recovery of injured pancreatic islets in zebrafish. Among them, compound blocked K channels in pancreatic β-cells. Furthermore, compounds , , and showed significant changes with respect to the mRNA expression of , , and compared to alloxan-induced zebrafish. In conclusion, the aerial part of and its constituents conferred a regenerative effect on injured pancreatic islets.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096680PMC
http://dx.doi.org/10.3390/nu15071798DOI Listing

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