EASIX Is an Accurate and Easily Available Prognostic Score in Critically Ill Patients with Advanced Liver Disease.

J Clin Med

Medizinische Klinik und Poliklinik II, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, D-81675 München, Germany.

Published: March 2023

AI Article Synopsis

  • Acute-on-chronic liver failure (ACLF) has high mortality rates, and accurate prognostic scores are crucial for treatment decisions, leading to the study of EASIX as a biomarker.
  • EASIX, which incorporates LDH, platelets, and creatinine, was tested in 188 liver cirrhotic patients to predict 28-day and 3-month mortality, demonstrating moderate to high accuracy compared to existing prognostic models.
  • Additionally, EASIX effectively ruled out early infections and predicted the need for hemodialysis, indicating its potential as a reliable and simple tool in managing advanced liver disease.

Article Abstract

Acute-on-chronic liver failure (ACLF) is associated with high mortality. Objective prognostic scores are important for treatment decisions. EASIX (Endothelial Activation and Stress Index) is a simple biomarker consisting of LDH, platelets, and creatinine, reflecting endothelial dysfunction after allogeneic stem cell transplantation. Considering endothelial dysfunction in the pathogenesis of ACLF, this study aimed to test the discriminative ability of EASIX in advanced liver disease. We retrospectively analysed the prognostic potential of EASIX to predict 28-day and 3-month mortality in a total of 188 liver cirrhotic patients requiring treatment at the intensive care unit. We evaluated the ability of EASIX to rule out early infections and predict the need for hemodialysis. EASIX performed moderately better than established scores in predicting 28-day mortality (AUC = 0.771) and was nearly equivalent (AUC = 0.791) to SOFA and APACHE-II in the prediction of 3-month mortality. Importantly, EASIX showed better diagnostic potential in ruling out clinically apparent infections than common proinflammatory markers (AUC = 0.861, < 0.001) and showed suitable accuracy in predicting the need for hemodialysis (AUC = 0.833). EASIX is an accurate, objective and easily assessable biomarker for predicting mortality and complications in patients with advanced liver disease.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094870PMC
http://dx.doi.org/10.3390/jcm12072553DOI Listing

Publication Analysis

Top Keywords

advanced liver
12
liver disease
12
easix
8
easix accurate
8
patients advanced
8
endothelial dysfunction
8
ability easix
8
3-month mortality
8
liver
5
mortality
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!