AI Article Synopsis
- * Research has shown that P2Y is also present in various immune cells, such as monocytes, dendritic cells, and T lymphocytes, leading to investigations on its role in inflammatory conditions like sepsis, cancer, and COVID-19.
- * The review discusses P2Y's expression in the immune system, its impact on inflammation, and the challenges faced in researching this receptor, along with potential solutions to these issues.
Article Abstract
P2Y is a G-protein-coupled receptor that is activated upon ADP binding. Considering its well-established role in platelet activation, blocking P2Y has been used as a therapeutic strategy for antiplatelet aggregation in cardiovascular disease patients. However, receptor studies have shown that P2Y is functionally expressed not only in platelets and the microglia but also in other cells of the immune system, such as in monocytes, dendritic cells, and T lymphocytes. As a result, studies were carried out investigating whether therapies targeting P2Y could also ameliorate inflammatory conditions, such as sepsis, rheumatoid arthritis, neuroinflammation, cancer, COVID-19, atherosclerosis, and diabetes-associated inflammation in animal models and human subjects. This review reports what is known about the expression of P2Y in the cells of the immune system and the effect of P2Y activation and/or inhibition in inflammatory conditions. Lastly, we will discuss the major problems and challenges in studying this receptor and provide insights on how they can be overcome.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095349 | PMC |
| http://dx.doi.org/10.3390/ijms24076709 | DOI Listing |
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