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Osteogenic Potential of Autologous Dentin Graft Compared with Bovine Xenograft Mixed with Autologous Bone in the Esthetic Zone: Radiographic, Histologic and Immunohistochemical Evaluation. | LitMetric

AI Article Synopsis

  • The study is a randomized clinical trial comparing autologous dentin graft (ADG) with a mixture of bovine xenograft and autologous bone (BX+AB) for bone augmentation after tooth extraction.
  • Both treatment groups showed similar results in terms of bone dimension loss and histological analysis, indicating no significant differences in overall efficacy.
  • However, there were notable differences in immunohistochemical staining results for TNF-α and BMP-4, suggesting ADG has effective biocompatibility and bone regeneration properties comparable to BX+AB in the maxillary region.

Article Abstract

This prospective, randomized, controlled clinical trial reports clinical, radiographic, histologic and immunohistochemical results of autologous dentin graft (ADG) and its comparison with a mixture of bovine xenograft with autologous bone (BX+AB). After tooth extraction in the esthetic zone of maxilla, the alveolar ridge of 20 patients in the test group was augmented with ADG, while 17 patients in the control group received the combination of BX+AB. Cone beam computed tomography (CBCT) was performed before tooth extraction and after 4 months when a total of 22 bone biopsies were harvested and subjected to histological and immunohistochemical analysis. Radiological analysis showed comparable results of bone dimension loss in both groups. Quantitative histologic analysis showed comparable results with no statistically significant differences between the groups. Immunohistochemical staining with TNF-α and BMP-4 antibodies revealed immunopositivity in both groups. A statistically significant difference between the groups was found in the intensity of TNF-α in the area of newly formed bone ( = 0.0003) and around remaining biomaterial particles ( = 0.0027), and in the intensity of BMP-4 in the area around biomaterial particles ( = 0.0001). Overall, ADG showed biocompatibility and achieved successful bone regeneration in the esthetic zone of the maxilla similar to BX+AB.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094989PMC
http://dx.doi.org/10.3390/ijms24076440DOI Listing

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