The term "neurodegenerative diseases" (NDs) identifies a group of heterogeneous diseases characterized by progressive loss of selectively vulnerable populations of neurons, which progressively deteriorates over time, leading to neuronal dysfunction. Protein aggregation and neuronal loss have been considered the most characteristic hallmarks of NDs, but growing evidence confirms that significant dysregulation of innate immune pathways plays a crucial role as well. NDs vary from multiple sclerosis, in which the autoimmune inflammatory component is predominant, to more "classical" NDs, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and spinal muscular atrophy. Of interest, many of the clinical differences reported in NDs seem to be closely linked to sex, which may be justified by the significant changes in immune mechanisms between affected females and males. In this review, we examined some of the most studied NDs by looking at their pathogenic and phenotypical features to highlight sex-related discrepancies, if any, with particular interest in the individuals' responses to treatment. We believe that pointing out these differences in clinical practice may help achieve more successful precision and personalized care.
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http://dx.doi.org/10.3390/ijms24076354 | DOI Listing |
J Sci Food Agric
December 2024
College of Agriculture, Shanxi Agricultural University, Taigu, China.
Background: In north China, wide-belt sowing (WBS) is widely used in wheat production because it increases the yield by improving the plant distribution and reducing the competition for resources compared with conventional narrow-drill sowing (NDS). Yield formation is also different for wheat varieties with distinct spike types. Therefore, it is important to explore the effects of WBS on the yields of wheat varieties with different spike types.
View Article and Find Full Text PDFLayered deposits are found on the plateaus surrounding the western portion of Valles Marineris, mantling the chasmata rims. These rim deposits exhibit intricate layering and are described as light-toned layered deposits (LLDs) in previous studies. Light-toned layered deposits are thought to be composed of pyroclastic ash that was emplaced during volcanic eruptions and later chemically altered.
View Article and Find Full Text PDFUrolithiasis
December 2024
Department of Urology, Oxford University Hospitals NHS Trust, Oxford, Oxfordshire, UK.
Purpose: To compare stone clearance and complications between a 'wide' (9 × 50 mm) and 'narrow' shockwave focus (6 × 28 mm) when undertaking shockwave lithotripsy (SWL) in patients with renal or ureteric stones.
Methods: Data from patients undergoing SWL using the dual focus Storz Modulith SLX-F2 lithotripter at a single centre were prospectively collected between February 2018 and September 2020. Patients were matched by stone size, location, and number of treatments.
J Great Lakes Res
June 2024
F.T Stone Laboratory, The Ohio State University, 878 Bayview Ave. Put-in-Bay, OH 43456, USA.
Cyanobacterial blooms in the western basin of Lake Erie have been well studied with a focus on planktonic and the cyanotoxin microcystin, but recent research has shown that blooms are not entirely . Previous studies have documented other taxa in blooms capable of producing other cyanotoxins. Furthermore, benthic cyanobacteria have historically been overlooked in Lake Erie.
View Article and Find Full Text PDFImmunol Invest
December 2024
Doping Research Chair, Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Background: Neurodegenerative diseases (NDs) have caused serious health issues worldwide. A growing body of evidence suggests a correlation between neuroinflammation and abnormal microglial activity with ND symptoms. Microglia survey play crucial roles in CNS during health and the injury.
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