Normal Pressure Hydrocephalus Following Cranial Radiation: Identification of Shunting Responders.

Cancers (Basel)

Neuro-Oncology Unit, Hospital Universitari de Bellvitge-Institut Català d'Oncologia l'Hospitalet, Institut d'Investigació Biomèdica de Bellvitge (Oncobell Program), 08908 L'Hospitalet de Llobregat, Barcelona, Spain.

Published: March 2023

Background: We examined cognitive, brain MRI, and lumbar infusion test (LIT) features to identify predictors of response to ventriculoperitoneal shunting (VPS) in long-term cancer survivors with suspected normal pressure hydrocephalus (NPH) following cranial radiotherapy (RT).

Methods: Patients who completed cranial RT at least 2 years before with clinically suspected NPH and an Evans' index (EI) ≥ 0.30 underwent a cognitive and a cerebrospinal fluid (CSF) volumetric (MRI) analysis ( = 36). For those in whom VPS was placed ( = 14), we explored whether adding a CSF volumetric analysis to classical MRI and LIT (Tap Test) features would better identify VPS responders.

Results: Nearly 80% exhibited cognitive impairment. The CSF volume at NPH diagnoses was significantly larger in the group of VPS responders ( = 0.04). The addition of CSF volume to NPH diagnoses increased accuracy to 93%, with a positive and negative predictive value of 91% and 100%, respectively.

Conclusion: The addition of a quantitative MRI analysis of CSF volume to classical MRI and LIT NPH criteria, along with a high clinical suspicion of NPH, may help to identify VPS responders, thus improving the clinical management and prognosis of long-term survivors.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093348PMC
http://dx.doi.org/10.3390/cancers15071949DOI Listing

Publication Analysis

Top Keywords

csf volume
12
normal pressure
8
pressure hydrocephalus
8
csf volumetric
8
mri analysis
8
classical mri
8
mri lit
8
identify vps
8
volume nph
8
nph diagnoses
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!