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Distinct checkpoint and homolog biorientation pathways regulate meiosis I in Drosophila oocytes.
PLoS Genet
January 2025
Waksman Institute, Rutgers, the State University of New Jersey, Piscataway, New Jersey, United States of America.
Mitosis and meiosis have two mechanisms for regulating the accuracy of chromosome segregation: error correction and the spindle assembly checkpoint (SAC). We have investigated the function of several checkpoint proteins in meiosis I of Drosophila oocytes. Increased localization of several SAC proteins was found upon depolymerization of microtubules by colchicine.
View Article and Find Full Text PDFAccuracy of latest large language models in answering multiple choice questions in dentistry: A comparative study.
PLoS One
January 2025
Faculty of Dentistry, PHENIKAA University, Hanoi, Vietnam.
Objectives: This study aims to evaluate the performance of the latest large language models (LLMs) in answering dental multiple choice questions (MCQs), including both text-based and image-based questions.
Material And Methods: A total of 1490 MCQs from two board review books for the United States National Board Dental Examination were selected. This study evaluated six of the latest LLMs as of August 2024, including ChatGPT 4.
Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder.
PLoS One
January 2025
Department of Psychiatry, University of California San Diego, La Jolla, CA, United States of America.
Background: Bipolar Disorder (BD) is a complex disease. It is heterogeneous, both at the phenotypic and genetic level, although the extent and impact of this heterogeneity is not fully understood. One way to assess this heterogeneity is to look for patterns in the subphenotype data.
View Article and Find Full Text PDFIntermediate-Term Outcomes and Complications of Ahmed Glaucoma Valve in Type 1 Keratoprostheses.
Cornea
January 2025
VST Centre for Glaucoma Care, L V Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India.
Purpose: To evaluate intermediate-term outcomes and complications associated with Ahmed glaucoma valve (AGV) implantation in eyes with type 1 keratoprosthesis (KPro).
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Prevalence and Clinical Associations of Peripapillary Hyperreflective Ovoid Mass-like Structures in Craniosynostosis.
J Neuroophthalmol
January 2025
Department of Ophthalmology (JGJ-C, TE, Y-HC, LRD, RAG), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts; Frank H. Netter Medical School (JGJ-C), North Haven, Connecticut; and Department of Anesthesiology (DZ), Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Background: Patients with craniosynostosis are at high risk of developing elevated intracranial pressure (ICP) causing papilledema and secondary optic atrophy. Diagnosing and monitoring optic neuropathy is challenging because of multiple causes of vision loss including exposure keratopathy, amblyopia, and cognitive delays that limit examination. Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are an optical coherence tomography (OCT) finding reported in association with papilledema and optic neuropathy.
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