During the past century eight species of sea hares of the genus Aplysia were recorded from Peru. However, there is disagreement about how many of these species are valid and their taxonomy needs to be critically evaluated. Based on detailed morphological examinations, this study presents a redescription of Aplysia nigra d'Orbigny, 1837 and Aplysia inca d'Orbigny, 1837, the most common species of Aplysia along the Peruvian coast. They showed consistent morphological differences, mainly in the foot, parapodia development, opaline gland, jaws, radular teeth and penial morphology. Anatomical data for both species are provided for the first time, as well as a comparison with other species of Aplysia reported for the Eastern Pacific. The records of Aplysia keraudreni Rang, 1828, Aplysia dactylomela Rang, 1828 and Aplysia juliana Quoy & Gaimard, 1832 for Peruvian waters are likely erroneous and need to be verified based on collected specimens.
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http://dx.doi.org/10.11646/zootaxa.5222.3.1 | DOI Listing |
Bio Protoc
January 2025
School of Systems Biology, George Mason University, Fairfax, VA, USA.
Nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels expressed in nervous and non-nervous system tissue important for memory, movement, and sensory processes. The pharmacological targeting of nAChRs, using small molecules or peptides, is a promising approach for the development of compounds for the treatment of various human diseases including inflammatory and neurogenerative disorders such as Alzheimer's disease. Using the acetylcholine binding protein (Ac-AChBP) as an established structural surrogate for human homopentameric α7 nAChRs, we describe an innovative protein painting mass spectrometry (MS) method that can be used to identify interaction sites for various ligands at the extracellular nAChR site.
View Article and Find Full Text PDFBioorg Chem
January 2025
Department of In Vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700026, India. Electronic address:
Histone deacetylases (HDACs) play a critical role in chromatin remodelling and modulating the activity of various histone proteins. Aberrant HDAC functions has been related to the progression of breast cancer (BC), making HDAC inhibitors (HDACi) promising small-molecule therapeutics for its treatment. Hydroxamic acid (HA) is a significant pharmacophore due to its strong metal-chelating ability, HDAC inhibition properties, MMP inhibition abilities, and more.
View Article and Find Full Text PDFBiophys J
January 2025
Michael Sars Centre, University of Bergen, Norway. Electronic address:
Neuropeptides are inter-cellular signaling molecules occurring throughout animals. Most neuropeptides bind and activate G-protein coupled receptors, but some also activate ionotropic receptors (or "ligand-gated ion channels"). This is exemplified by the tetra-peptide H-Phe-Met-Arg-Phe-NH (FMRFa), which activates mollusc and annelid FMRFa-gated sodium channels (FaNaCs) from the trimeric degenerin/epithelial sodium channel superfamily.
View Article and Find Full Text PDFChem Biodivers
December 2024
Department of Applied Chemistry, Innovation Center of Pesticide Research, College of Science, China Agricultural University, Beijing, P. R. China.
The development of novel insecticides with low bee toxicity has become increasingly urgent as many high bee-toxicity neonicotinoids have been progressively restricted. In this study, novel halogenated phenyl-substituted α-butenolide compounds were designed, optimized and synthesized through a progressive strategy based on insect nicotinic acetylcholine receptor and the calculated oil-water partition coefficient (ClogP) of compounds. Among these, the difluorophenyl-substituted compound 3cj (lethal medium concentration [LC] = 40.
View Article and Find Full Text PDFMol Biotechnol
November 2024
Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, 570015, Karnataka, India.
Whether it involves human subjects or non-human animals, basic, translational, or clinical sleep research poses significant ethical challenges for researchers and ethical committees alike. Sleep research greatly benefits from using diverse animal models, each offering unique insights into sleep control mechanisms. The fruit fly (Drosophila melanogaster) is a superior genetic model due to its quick generation period, large progenies, and rich genetic tools.
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