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| http://dx.doi.org/10.1001/jamanetworkopen.2023.7707 | DOI Listing |
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Oppositional and competitive instigation of hippocampal synaptic plasticity by the VTA and locus coeruleus.
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Department of Neurophysiology, Medical Faculty, Ruhr University Bochum, Bochum 44780, Germany.
The novelty, saliency, and valency of ongoing experiences potently influence the firing rate of the ventral tegmental area (VTA) and the locus coeruleus (LC). Associative experience, in turn, is recorded into memory by means of hippocampal synaptic plasticity that is regulated by noradrenaline sourced from the LC, and dopamine, sourced from both the VTA and LC. Two persistent forms of synaptic plasticity, long-term potentiation (LTP), and long-term depression (LTD) support the encoding of different kinds of spatial experience.
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Center for Evaluation and Survey Research, HealthPartners Institute, Bloomington, MN, United States.
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View Article and Find Full Text PDFHow breakthroughs happen: Unearthing the boundary conditions of eco-friendly deliberate practice and eco-innovation performance.
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