AI Article Synopsis
- - This study investigates the protective effects of boric acid on female rat oocytes exposed to nonylphenol (NP), highlighting its potential in preserving ovarian quality and function.
- - Histopathological and biochemical analyses revealed that boric acid mitigated tissue damage, restored hormone levels, and provided DNA protection, suggesting its positive impact on ovarian health.
- - The findings indicate that boric acid may effectively counteract the negative effects of NP, reducing oxidative stress and inflammation, and thus plays a protective role against infertility caused by NP exposure.
Article Abstract
In this study, we reported boric acid's protective effects on the quality of nonylphenol (NP)-exposed oocytes. Female rats were classified into 4 groups: control, boric acid, NP, and NP+boric acid. Histopathological studies and immunohistochemical analysis of anti-müllerian hormone (AMH), mechanistic target of rapamycin (mTOR), Sirtuin1 (SIRT1), stem cell factor (SCF) studies were done. The comet assay technique was utilized for DNA damage. The ELISA method was used to determine the concentrations of oxidative stress indicators (SOD, CAT, and MDA), ovarian hormone (INH-B), and inflammation indicators (IL-6 and TNF-α). Boric acid significantly reduced the histopathological alterations and nearly preserved the ovarian reserve. With the restoration of AMH and SCF, boric acid significantly improved the ovarian injury. It downregulated SIRT1 and upregulated the mTOR signaling pathway. It provided DNA damage protection. Ovarian SOD, CAT levels were decreased by boric acid. Boric acid co-administration significantly reduced NP's MDA, IL-6, and TNF-activities. This results imply that boric acid has a protective role in ovarian tissue against NP-mediated infertility.
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| http://dx.doi.org/10.1007/s12011-023-03657-5 | DOI Listing |
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