A new chromone from endophytic fungus sp. ZJ-68.

J Asian Nat Prod Res

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, South China Normal University, Guangzhou 510631, China.

Published: November 2023

One chromone (), together with four known alkaloids, were isolated from the mangrove endophytic fungus sp. ZJ-68. Their structures were elucidated by a combination of HRESIMS and NMR spectroscopic analyses. Compound showed strong anti-inflammatory activity by inhibiting nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 cells with an IC value of 4.094 ± 0.8 μM, which was better than positive drug indomethacin (IC=35.8 ± 0.5 μM).

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http://dx.doi.org/10.1080/10286020.2023.2197226DOI Listing

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