AI Article Synopsis
- Sulfur-arylation of sulfenamides was achieved using a Chan-Lam-type coupling method with boronic acids, resulting in the formation of sulfilimines.
- A wide variety of aryl and alkyl sulfenamides and boronic acids were successfully utilized, showcasing the reaction's versatility.
- The research also highlighted the potential for integrating sulfilimines into existing drugs and further transforming these products into valuable medicinal compounds like sulfoximines and sulfondiimines.
Article Abstract
Sulfur-arylation of sulfenamides is reported. This reaction proceeds via a Chan-Lam-type coupling with commercially abundant boronic acids to give sulfilimines. A broad scope was established with a variety of readily accessible aryl and alkyl sulfenamide and boronic acid inputs. Synthetic utility and functional group compatibility were further demonstrated through the direct late-stage introduction of sulfilimines into approved drugs. Derivatization of the sulfilimine products provided access to medicinally relevant sulfoximines and sulfondiimines.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163624 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.3c00779 | DOI Listing |
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Article Synopsis
- Sulfur-arylation of sulfenamides was achieved using a Chan-Lam-type coupling method with boronic acids, resulting in the formation of sulfilimines.
- A wide variety of aryl and alkyl sulfenamides and boronic acids were successfully utilized, showcasing the reaction's versatility.
- The research also highlighted the potential for integrating sulfilimines into existing drugs and further transforming these products into valuable medicinal compounds like sulfoximines and sulfondiimines.
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