AI Article Synopsis
- Marine bacteria are a promising source for developing new drug therapies, particularly through their unique components called lipopolysaccharides (LPSs).
- A study focused on lipid A from three types of marine bacteria showed a diverse mix of lipid A compounds, mostly featuring specific molecular structures like one phosphate and one D-mannose.
- Among the studied bacteria, C. algicola ACAM 630 was found to be more effective at activating immune responses compared to C. baltica NNO 15840 and C. tyrosinoxydans EM41, suggesting varying potential in their immune system interactions.
Article Abstract
Marine bacteria, which are often described as chemical gold, are considered an exceptional source of new therapeutics. Considerable research interest has been given to lipopolysaccharides (LPSs), the main components of the Gram-negative outer membrane. LPS and its lipid A portion from marine bacteria are known to exhibit a tricky chemistry that has been often associated with intriguing properties such as behaving as immune adjuvants or anti-sepsis molecules. In this scenario, we report the structural determination of the lipid A from three marine bacteria within the Cellulophaga genus, which showed to produce an extremely heterogenous blend of tetra- to hexa-acylated lipid A species, mostly carrying one phosphate and one D-mannose on the glucosamine disaccharide backbone. The ability of the three LPSs in activating TLR4 signaling revealed a weaker immunopotential by C. baltica NNO 15840 and C. tyrosinoxydans EM41 , while C. algicola ACAM 630 behaved as a more potent TLR4 activator.
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| http://dx.doi.org/10.1002/cbic.202300183 | DOI Listing |
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