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Application of novel strategies in chronic wound management with focusing on pressure ulcers: new perspective.
Arch Dermatol Res
January 2025
Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.
Invading blood cells, extracellular tissue, and soluble mediators all play important roles in the wound-healing process. There is a substantial global burden of disease and mortality attributable to skin defects that do not heal. About 1% to 2% of the population in industrialized nations suffers from chronic wounds that don't heal, despite healthcare breakthroughs; this condition is very costly, costing about $25 billion each year in the US alone.
View Article and Find Full Text PDFRevealing the promising era of silk-based nanotherapeutics: a ray of hope for chronic wound healing treatment.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, Pushp Vihar, New Delhi, 110017, India.
Chronic wounds significantly contribute to disability and affect the mortality rate in diabetic patients. In addition, pressure ulcers, diabetic foot ulcers, arterial ulcers, and venous ulcers pose a significant health burden due to their associated morbidity and death. The complex healing process, environmental factors, and genetic factors have been identified as the rate-limiting stages of chronic wound healing.
View Article and Find Full Text PDFThree-dimensional differences in plantar surface shape captured by methods used for custom accommodative insole design.
J Foot Ankle Res
March 2025
VA RR&D Center for Limb Loss and MoBility (CLiMB), VA Puget Sound Health Care System, Seattle, WA, USA.
Background: The patient-specific shape of custom accommodative insoles for individuals with diabetes provides full foot-to-insole contact, offloading areas with high plantar pressures and reducing ulceration risk. To design the insole surface, plantar surface shape is captured, traditionally with a foam crush box impression or more recently with 3D scans of the foot. Beyond discrete measurements of the foot, the overall plantar surface shapes obtained from these different methods have yet to be compared, however, differences in the shapes captured by these methods may affect the insole's surface geometry design and subsequent performance.
View Article and Find Full Text PDFMaladaptive Peripheral Ketogenesis in Schwann Cells Mediated by CBR Contributes to Diabetic Neuropathy.
Adv Sci (Weinh)
January 2025
Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes. Although studies have previously investigated metabolic disruptions in the peripheral nervous system (PNS), the exact metabolic mechanisms underlying DPN remain largely unknown. Herein, a specific form of metabolic remodeling involving aberrant ketogenesis within Schwann cells (SCs) in streptozotocin (STZ)-induced type I diabetes mellitus is identified.
View Article and Find Full Text PDFProbiotic active gel promotes diabetic wound healing through continuous local glucose consumption and antioxidant.
J Nanobiotechnology
January 2025
Shandong Key Laboratory of Proteins and Peptides Pharmaceutical Engineering, Shandong Universities Key Laboratory of Biological Medicine, School of Life Science and Technology, Shandong Second Medical University, 7166 # Baotong West Street, Weifang, Shandong, 261053, People's Republic of China.
Background: Diabetic foot ulcers (DFU) are severe complications of diabetes, posing significant health and societal challenges. Accumulation of reactive oxygen species (ROS) and elevated glucose levels are primary factors affecting diabetic wound healing. Achieving effective treatment by reducing ROS alone is challenging, as high glucose levels continuously drive ROS production.
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