AI Article Synopsis
- - The study investigated the characteristics of asthma patients needing one-day systemic corticosteroid (SB) treatments, revealing that only 2.6% of patients fell into this category, primarily being female, obese, and non-atopic.
- - One-day SB was mostly self-administered by patients, with a median occurrence of 1.5 times a year, and was linked to a significantly higher likelihood of experiencing frequent SB in the future.
- - The findings suggest the importance of understanding the implications of one-day SB treatments, as they can lead to more frequent exacerbations even without prior conventional SB usage.
Article Abstract
Objective: Systemic corticosteroid administration, also called short bursts (SB), is harmful for patients with asthma; however, the actual burden of one-day SB remains unsolved. This study aimed to elucidate the characteristics of patients requiring one-day SB against asthma in clinical practice.
Methods: Consecutive patients who regularly visited our hospital for asthma treatment between January 2019 and December 2020 were reviewed and followed for one year. SB was defined as ≥3 days of systemic corticosteroid treatment for an exacerbation. One-day SB was defined as one-day of systemic corticosteroid to treat an exacerbation. The one-day SB group included patients who received only one-day SB but no SB during the preceding year. Frequent SB was defined as that occurring ≥2 times/year.
Results: Data on 229 patients were analyzed. Among them, 2.6% (95% confidence interval 1.2-5.6%) were in the one-day SB group. The one-day SB group was female-dominant, obese, non-eosinophilic, and non-atopic. The median one-day SB was 1.5 times/year and almost half of one-day SB were performed by patients themselves. Independent of the low pulmonary function, high blood eosinophil count, and inhaled corticosteroid dose, one-day SB was associated with future frequent SB (adjusted odds ratio = 18.2, 95% confidence interval 1.1-288, = 0.040, compared to the no SB group).
Conclusions: Although one-day SB was not frequently experienced, even one-day SB without conventional SB was associated with future frequent SB. It is important to grasp the actual condition of one-day SB and to reinforce the treatment used.
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| http://dx.doi.org/10.1080/02770903.2023.2200854 | DOI Listing |
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