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Anaplastic Kaposi Sarcoma of the Right Colon, in a Young Man With Acquired Immunodeficiency Syndrome: A Rare Variant in an Unreported Organ.
Int J Surg Pathol
May 2024
Department of Pathology, Instituto Nacional de Cancerología, Ciudad de México, México.
Kaposi sarcoma (KS) arises in the context of 4 epidemiologic-clinical settings: Classic, endemic, epidemic, and iatrogenic; the most serious types are endemic and epidemic, and visceral involvement occurs mostly in the latter. Several morphological variants of KS have been described, of which the anaplastic one is highly aggressive. We report the case of an anaplastic KS arising from the ascending colon in a 32-year-old human immunodeficiency virus (HIV)-positive male patient with a 6-year history of multiple mucocutaneous KS.
View Article and Find Full Text PDFAnaplastic Kaposi Sarcoma: A Clinicopathologic and Molecular Genetic Analysis.
Mod Pathol
August 2023
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:
Kaposi sarcoma (KS) is a human herpesvirus 8 (HHV8)-associated vascular proliferation that most often involves the skin. Rarely, KS shows marked nuclear atypia or pleomorphism; such examples are known as "anaplastic" KS. This poorly characterized variant often pursues an aggressive course; little is known of its genetic landscape.
View Article and Find Full Text PDFAnaplastic Kaposi sarcoma.
Histopathology
July 2023
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.
Anaplastic Classic Kaposi Sarcoma: PD-L1 Expression and Response to Immunotherapy: A Case Report and Review of the Literature.
J Natl Compr Canc Netw
April 2023
Histopathology Unit of National Institute of Gastroenterology "S. De Bellis, " Research Hospital Castellana Grotte, Bari, Italy.
Anaplastic classic Kaposi sarcoma (CKS) is an extremely rare pathologic variant of CKS characterized by high aggressiveness and poor prognosis. We report the clinical course of this malignant histologic form in an otherwise healthy 67-year-old male from Apulia in Southern Italy. The anaplastic progression arose during a long history of CKS and developed after multiple local and systemic treatments.
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