AI Article Synopsis
- Mesenchymal stem cells (MSCs) are versatile cells that can become different types of tissues like bone, cartilage, muscle, and fat, making them valuable for medical treatments.
- Numerous studies and trials have tested MSC-based therapies for treating various inflammatory and degenerative diseases, showing promise despite challenges in widespread application.
- The review focuses on advanced techniques to enhance the therapeutic effectiveness of MSCs, including the use of drugs, cytokines, and growth factors, highlighting their potential mechanisms and future applications in cellular therapy.
Article Abstract
Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a range of cell types, including osteoblasts, chondrocytes, myocytes, and adipocytes. Multiple preclinical investigations and clinical trials employed enhanced MSCs-dependent therapies in treatment of inflammatory and degenerative diseases. They have demonstrated considerable and prospective therapeutic potentials even though the large-scale use remains a problem. Several strategies have been used to improve the therapeutic potency of MSCs in cellular therapy. Treatment of MSCs utilizing pharmaceutical compounds, cytokines, growth factors, hormones, and vitamins have shown potential outcomes in boosting MSCs' stemness. In this study, we reviewed the current advances in enhancing techniques that attempt to promote MSCs' therapeutic effectiveness in cellular therapy and stemness in vivo with potential mechanisms and applications.
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| http://dx.doi.org/10.1016/j.biopha.2023.114356 | DOI Listing |
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