The authors of a recent study identified noncanonical peptides (NCP) presented by cancer cells' HLA and observed lack of reactivity to these antigens by endogenous tumor-reactive T cells. In vitro sensitization generated NCP-reactive T cells that recognized epitopes shared by a majority of cancers tested, providing opportunities for novel therapies to shared antigens. See related article by Lozano-Rabella et al., p. 2250.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261915 | PMC |
| http://dx.doi.org/10.1158/1078-0432.CCR-23-0422 | DOI Listing |
Publication Analysis
Top Keywords
cancer's dark
4
dark matter
4
matter lighting
4
lighting abyss
4
abyss unveils
4
unveils universe
4
universe therapies
4
therapies authors
4
authors study
4
study identified
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!