Objectives: The aim of this retrospective study was to assess the long-term results of root remodelling with tricuspid aortic valves and the effects of concomitant cusp repair and annuloplasty.
Methods: Between October 1995 and December 2021, 684 patients with root aneurysm and regurgitant tricuspid valves were treated by root remodelling. The mean age was 56.5 [standard deviation (SD): 14] years, and 538 (77.6%) were male. Relevant aortic regurgitation was present in 68.3%. Concomitant procedures were performed in 374 patients. The long-term results were analysed. The mean follow-up of 7.2 (SD: 5.3) years (median 6.6 years); it was 95% complete (4934.4 patient-years).
Results: Cusp prolapse was repaired in 83%, and an annuloplasty was added in 353 instances (51.6%). Hospital mortality was 2.3%, and survival was 81.7% (SD: 1.2) and 55.7% (SD: 5.8) at 10 and 20 years; age and measurement of effective height were independent predictors for death. Freedom from Aortic insufficiency (AI) II was 90.5 (SD: 1.9) at 10 years and 76.7 (SD: 4.5) at 20 years. Cusp repair of all cusps showed a lower freedom from recurrent AI ≥II at 10 years (P < 0.001). Suture annuloplasty showed a lower freedom from recurrent AI II at 10 years (P = 0.07). Freedom from reoperation was 95.5 (SD: 1.1) and 92.8 (SD: 2.8) at 10 and 20 years. The addition of an annuloplasty showed no difference (P = 0.236). Cusp repair had no effect on valve durability (P = 0.390).
Conclusions: Root remodelling leads to good long-term stability. The addition of cusp repair improves the valve stability over time. The addition of suture annuloplasty improves early valve competency; it showed no effect on freedom from reoperation up to 10 years.
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http://dx.doi.org/10.1093/ejcts/ezad137 | DOI Listing |
J Integr Med
March 2025
Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou Zhejiang Province, 310053, China. Electronic address:
Objective: Treating peripheral nerve injury (PNI) presents a clinical challenge due to limited axon regeneration. Strychni Semen, a traditional Chinese medicine, is clinically used for numbness and hemiplegia. However, its role in promoting functional recovery after PNI and the related mechanisms have not yet been systematically studied.
View Article and Find Full Text PDFOrthod Craniofac Res
March 2025
Department of Orthodontics and Dentofacial Orthopedics, Eastman Institute for Oral Health, University of Rochester, Rochester, New York, USA.
Objective: To evaluate the radiographic presence and magnitude of alveolar bone dehiscences (ABDs) and fenestrations (ABFs) in maxillary and mandibular anterior teeth of adults with dental Class II malocclusion, before (T1), immediately after (T2), and up to 2 years after (T3) non-extraction clear aligner therapy (CAT).
Setting And Sample Population: Records from 14 adults with dental Class II malocclusion treated with non-extraction CAT and Class II elastics were retrospectively obtained.
Materials And Methods: A total of 332 labial and lingual anterior root surfaces were assessed using cone beam computed tomography (CBCT) at T1, T2 and T3.
Plant J
March 2025
Department of Biochemistry, University of Missouri, Columbia, Missouri, 65211, USA.
Bioengineering efforts to increase oil in non-storage vegetative tissues, which constitute the majority of plant biomass, are promising sustainable sources of renewable fuels and feedstocks. While plants typically do not accumulate significant amounts of triacylglycerol (TAG) in vegetative tissues, we report here that the expression of a plastid-localized phospholipase A1 protein, DEFECTIVE IN ANTHER DEHISCENCE1 (DAD1), led to a substantial increase in leaf TAG in Arabidopsis. Using an inducible system to control DAD1 expression circumvented growth penalties associated with overexpressing DAD1 and resulted in a rapid burst of TAG within several hours.
View Article and Find Full Text PDFPhilos Trans R Soc Lond B Biol Sci
March 2025
School of BioSciences, The University of Melbourne, Parkville, Victoria, Australia.
Plant acclimation occurs through system-wide mechanisms that include proteome shifts, some of which occur at the level of protein synthesis. All proteins are synthesized by ribosomes. Rather than being monolithic, transcript-to-protein translation machines, ribosomes can be selective and cause proteome shifts.
View Article and Find Full Text PDFFront Plant Sci
February 2025
College of Resource and Environment, Anhui Agricultural University, Hefei, China.
Low-temperature stress has become a major limiting factor for the sustainable production of forage crops and animal husbandry. This experimental study evaluated the effects of optimizing phosphorus application on the antioxidant properties and carbon-nitrogen metabolism physiology of alfalfa ( L.) under LT stress, aiming to provide a reference for efficient stress-resistant alfalfa production.
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