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Postnatal undernutrition increases estradiol plasma levels and sexual receptivity and disrupts the kisspeptin-GnRH pathway in adult female rats.
Physiol Behav
January 2025
University of Northern Parana (UNOPAR), Londrina, PR, Brazil.. Electronic address:
Undernutrition has increased worldwide in recent years and it is known that environmental factors to which individuals are exposed in early life can result in metabolic and reproductive changes that remain in adult life. In this context, the litter size expansion is a classic model used to induce undernutrition early in development. Thus, this study aimed to evaluate the effects of neonatal undernutrition induced by the litter size expansion on metabolic and reproductive parameters of female rats.
View Article and Find Full Text PDFEffect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot study.
J Pediatr Endocrinol Metab
January 2025
Department of Paediatrics, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Objectives: Kisspeptin plays a major role in the onset of puberty by stimulating the gonadotropin-releasing hormone (GnRH) neurons. The aim of this study was to investigate whether GnRH inhibits kisspeptin secretion via a negative feedback mechanism and potential associations between kisspeptin levels and other hormones of importance for pubertal onset.
Methods: Thirteen girls with suspected central precocious puberty underwent a GnRH stimulation test twice in a randomized, placebo-controlled manner.
Central administration of p234, kisspeptin antagonist, but not kisspeptin-10, reduces the power of epileptiform activity and slow EEG waves in male rats.
Neurol Res
January 2025
Faculty of Medicine, Department of Biophysics, Karadeniz Technical University, Trabzon, Turkey.
Introduction: We aimed to investigate the effects of central kisspeptin-10 and p234 administration on basal brain activity and epilepsy-like conditions induced by 4-aminopyridine (4-AP), as well as their roles in the electrocorticogram (ECoG) power spectrum and EEG waves.
Methods: Thirty-five male Wistar rats were divided into five groups: sham,4-AP (2.5 mg/kg i.
The Influence of Artificial Light Exposure on Indigenous Populations: Exploring Its Impact on Menarcheal Age and Reproductive Function.
J Reprod Infertil
January 2024
Departments of Anatomy and Physiology, Edo State University Uzairue, Auchi, Nigeria.
The impact of artificial light exposure on human health has garnered significant attention in recent years. In particular, its effects on reproductive health have raised concerns. Given that the onset of menarche serves as a crucial indicator of reproductive maturity, understanding the implications of artificial light exposure becomes paramount.
View Article and Find Full Text PDFPerinatal exposure to bisphenol A or S alters differently sexual behavior and kisspeptin system in mice.
Environ Res
January 2025
Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole, 10-10043, Orbassano, Turin, Italy; Department of Neuroscience "Rita Levi-Montalcini", University of Turin, Via Cherasco 15, 10126, Turin, Italy.
The effects of bisphenol A (BPA), a highly diffused endocrine-disrupting chemical found mainly in plastics, on neural circuits and behaviors are well-known. However, the effects of its substitutes have not been fully investigated. Thus, in the present study, we compare the effects of perinatal exposure to bisphenol A or S (BPS) on reproductive behaviors and related hypothalamic kisspeptin system in mice.
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