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Visceral Pain in Preterm Infants with Necrotizing Enterocolitis: Underlying Mechanisms and Implications for Treatment.
Paediatr Drugs
January 2025
Department of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
Necrotizing enterocolitis (NEC) is a relatively rare but very severe gastrointestinal disease primarily affecting very preterm infants. NEC is characterized by excessive inflammation and ischemia in the intestines, and is associated with prolonged, severe visceral pain. Despite its recognition as a highly painful disease, current pain management for NEC is often inadequate, and research on optimal analgesic therapy for these patients is lacking.
View Article and Find Full Text PDFOral Food Challenge Protocols in Food Protein-Induced Enterocolitis Syndrome: A Systematic Review.
J Allergy Clin Immunol Pract
December 2024
Section of Inflammation, Repair and Development, National Heart and Lung Institute. Imperial College London, London, UK. Electronic address:
Background: Oral Food Challenges (OFC) are essential for the diagnosis and follow-up of acute Food Protein-Induced Enterocolitis Syndrome (FPIES) because no diagnostic or prognostic biomarkers are available. However, the optimal OFC procedure remains unclear.
Objectives: This systematic review aimed to assess OFC procedures' design and clinical outcomes in patients with FPIES.
Pediatric endoscopic sinus surgery: Revisited 35 years later.
Am J Otolaryngol
December 2024
Department of Otolaryngology - Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, United States of America.
Over the past 35 years, pediatric endoscopic sinus surgery (PESS) has significantly evolved from its inception as a novel intervention to become a cornerstone in the management of pediatric sinus disorders. This evolution is reflective of a broader shift towards a more nuanced understanding and treatment of pediatric chronic rhinosinusitis (PCRS), marked by the introduction of comprehensive guidelines and the refinement of surgical indications. Recent literature and the extensive experience of the senior author, who has been at the forefront of utilizing PESS since its inception, highlight a noticeable shift in the procedure's utilization.
View Article and Find Full Text PDFCommunication About Sudden Unexpected Death in Epilepsy: An Adaptation of the SPIKES Protocol.
Pediatr Neurol
October 2024
Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina. Electronic address:
Background: Sudden unexpected death in epilepsy (SUDEP) is a common cause of premature death in children and adults with epilepsy. People with epilepsy and their caregivers prefer the risk of SUDEP to be disclosed by their clinicians; however, few tools exist to support these conversations.
Methods: We aimed to (1) characterize SUDEP communication preferences of clinicians and caregivers of children with epilepsy, and (2) leverage these preferences to develop a conversation guide to support the discussion of SUDEP risk.
Cerebrospinal Fluid Cytology in Lyme Neuroborreliosis Revisited-Role of Neutrophilic Granulocytes: A Retrospective Single-Center Study.
J Clin Med
December 2024
Department of Neurology, Christian-Doppler University Hospital, Paracelsus Medical University, Centre for Cognitive Neuroscience, Ignaz Harrer Str. 79, 5020 Salzburg, Austria.
: diagnosis of Lyme neuroborreliosis (LNB) relies on medical history, clinical findings, and detection of pathogen-specific antibodies in the blood and cerebrospinal fluid (CSF). The chemoattractant CXCL13 serves as an additional marker for LNB acuity. During the diagnostic workup, cytomorphological examination of immune cells in CSF provides early insights.
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