Objective: There is a lack of established biological, psychological, social, and digital markers for the prediction, identification, and stratification of patients with major depressive disorder (MDD). We therefore aimed to evaluate serum nerve growth factor (NGF) in MDD patients.
Methods: In this case-control study, we recruited MDD patients and age- and sex-matched healthy controls (HCs). A qualified psychiatrist evaluated study participants according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition. Serum NGF levels were analyzed using a commercially available enzyme-linked immunosorbent assay kit.
Results: We analyzed data from 106 MDD patients and 88 HCs. Mean serum NGF concentrations were significantly higher in MDD patients (104.70 ± 6.43 pg/mL) than in HCs (72.09 ± 7.69 pg/mL). Receiver operating characteristic curve analysis revealed the good diagnostic performance of serum NGF in MDD.
Conclusions: Higher serum NGF levels might be involved in MDD pathophysiology, and altered NGF levels may be an early warning sign of depression. The present findings will aid in the development of new and improved therapies for depressive patients. Further interventional studies are recommended to explore the underlying mechanisms, risk factors, disease course, and treatment responses of NGF in MDD.
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| http://dx.doi.org/10.1177/03000605231166222 | DOI Listing |
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Article Synopsis
- The study investigates how serum biomarkers and substance use predict the conversion from major depressive disorder (MDD) to bipolar disorder (BD) in adults.
- The conversion rate from MDD to BD was found to be 12.4%, with higher incidences among women and those with specific educational backgrounds and cocaine use.
- The analysis indicated a notable interaction between nerve growth factor (NGF) levels and cocaine use, suggesting these factors may contribute to the diagnostic conversion and, if untreated, could lead to poorer outcomes in BD prognosis.
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