Association of Caffeine Consumption and Brain Amyloid Positivity in Cognitively Normal Older Adults.

J Alzheimers Dis

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit (No. 2018RU006), Peking University, Beijing, China.

Published: May 2023

AI Article Synopsis

  • * Results show no overall significant relationship between caffeine intake and amyloid positivity, but a notable inverse relationship was found in males, meaning caffeine may reduce the risk of amyloid presence for them.
  • * No significant effect of caffeine was observed for females, and the research indicates further investigations are necessary to understand the underlying mechanisms of caffeine's influence on brain health.

Article Abstract

Background: Several epidemiological studies have reported the protective role of caffeine on health outcomes; however, it remained debatable on caffeine consumption and brain amyloid positivity.

Objective: We aimed to determine the relationship between caffeine consumption and brain amyloid pathology in cognitively normal older adults.

Methods: The dataset used for analysis in this cross-sectional study was selected from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) Study. Multivariable logistic regression analyses were performed to explore the association between caffeine consumption and amyloid positivity using odds ratios (ORs) and 95% confidence intervals (CIs).

Results: In total, 4,394 participants were included in the final analysis. No significant association between caffeine consumption and amyloid positivity was observed in the whole participants (OR, 0.95; 95% CI, 0.78-1.14; p = 0.558). Subgroup analysis showed that caffeine intake was significantly associated with decreased amyloid positivity in males (OR, 0.72; 95% CI, 0.54-0.97; p = 0.032) but not in females (OR, 1.14; 95% CI, 0.90-1.46; p = 0.280), and the association between caffeine and amyloid positivity was not affected by age or APOE genotypes. In addition, different levels of caffeine were not associated with amyloid positivity.

Conclusion: The findings suggest that caffeine consumption was not significantly associated with amyloid positivity in the whole sample. However, caffeine consumption may be inversely associated with amyloid positivity among males but not females. More studies are needed to explore the mechanisms underlying caffeine consumption and brain amyloid positivity.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200149PMC
http://dx.doi.org/10.3233/JAD-220591DOI Listing

Publication Analysis

Top Keywords

caffeine consumption
32
amyloid positivity
32
association caffeine
16
consumption brain
16
brain amyloid
16
associated amyloid
12
amyloid
11
caffeine
11
consumption
8
positivity
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!