AI Article Synopsis
- The study examined how different metabolic syndrome-body mass index (MetS-BMI) phenotypes affect the risk of developing kidney stones.
- A total of 13,589 participants aged 20-80 from NHANES data were analyzed, and those with obesity and metabolic dysfunction showed significantly higher risks for kidney stones.
- The findings suggest that both obesity and poor metabolic health contribute to increased kidney stone risk, highlighting the importance of assessing metabolic status for prevention.
Article Abstract
Background: This study aimed to investigate the association between different metabolic syndrome-body mass index (MetS-BMI) phenotypes and the risk of kidney stones.
Materials And Methods: Participants aged 20-80 years from six consecutive cycles of the NHANES 2007-2018 were included in this study. According to their MetS status and BMI, the included participants were allocated into six mutually exclusive groups: metabolically healthy normal weight (MHN)/overweight (MHOW)/obesity (MHO) and metabolically unhealthy normal weight (MUN)/overweight (MUOW)/obesity (MUO). To explore the association between MetS-BMI phenotypes and the risk of kidney stones, binary logistic regression was used to determine the odds ratios (ORs).
Results: A total of 13,589 participants were included. It was revealed that all the phenotypes with obesity displayed higher risks of kidney stones (OR = 1.38, < 0.01 for MHO & OR = 1.80, < 0.001 for MUO, in the fully adjusted model). The risk increased significantly when metabolic dysfunction coexisted with overweight and obesity (OR = 1.39, < 0.05 for MUOW & OR = 1.80, < 0.001 for MUO, in the fully adjusted model). Of note, the ORs for the MUO and MUOW groups were higher than those for the MHO and MHOW groups, respectively.
Conclusions: Obesity and unhealthy metabolic status can jointly increase the risk of kidney stones. Assessing the metabolic status of all individuals may be beneficial for preventing kidney stones.
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| http://dx.doi.org/10.1080/13685538.2023.2195932 | DOI Listing |
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