Objective: This study aims to investigate and compare the establishment of dentinal cracks during root canal preparation using a stereomicroscope and a scanning electron microscope (SEM).
Materials And Methods: Sixty removed human mandibular premolars were separated into three groups of 20: two experimental and one control. Within the randomized controlled experimental groups, root canals were constructed. Group I: the Waldent walflex file and Group II: the Trunatomy (TRN) file. Group III: the control group received no preparations. The surfaces of the roots were checked for dentinal cracks using a stereomicroscope and SEM following sectioning at 3, 6, and 9 mm from the apex. The Chi-square test was used to examine the data.
Results: In the control group, no fissures appeared. Cracks in Waldent Walflex were almost 66.7% between the 3mm and 6mm range. At both the 6 mm and 9 mm levels, there was no statistically significant difference between the experimental groups (P > 0.05). Defects were found to be substantially higher in the apical region of samples than in the median and coronal sections.
Conclusion: Dentinal fissures were created by every rotary file used in the tests. There were more flaws in the Waldent Walflex file group than in the Trunatomy file group.
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http://dx.doi.org/10.7759/cureus.35914 | DOI Listing |
Nat Aging
December 2024
Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
The emerging field of senolytics is centered on eliminating senescent cells to block their contribution to the progression of age-related diseases, including cancer, and to facilitate healthy aging. Enhancing the selectivity of senolytic treatments toward senescent cells stands to reduce the adverse effects associated with existing senolytic interventions. Taking advantage of lipofuscin accumulation in senescent cells, we describe here the development of a highly efficient senolytic platform consisting of a lipofuscin-binding domain scaffold, which can be conjugated with a senolytic drug via an ester bond.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
December 2024
Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Purpose: The rarity of breast mucinous carcinoma (BMC) makes it challenging to study the prognosis of this disease across diverse racial populations. This study aimed to leverage epidemiological data on immigrant populations to elucidate the prognostic differences in BMC patients from various racial/ethnic backgrounds. The goal was to help formulate more personalized clinical practice guidelines for the management of this rare malignancy.
View Article and Find Full Text PDFFront Oral Health
December 2024
Department of Substitutive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Objectives: The influence of printing parameters on the marginal and internal fit of three-dimensional (3D) printed interim fixed partial dentures (IFPDs) has been understudied. This investigation sought to elucidate the impact of printing orientation and post-curing time on these critical factors.
Methods: A total of 260 3-Unit IFDPs were printed using two different resins (130/NextDent C&B MFH and 130/ASIGA DentaTOOTH).
Equine Vet J
December 2024
Department of Large Animal Surgery, Anaesthesia and Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
Background: In orthograde endodontic treatments, different methods are available to debride the pulp canals of endodontically compromised equine cheek teeth, but their efficacy is unknown.
Objectives: To explore and compare the efficacy and anatomical changes caused by manual versus reciprocating filing techniques in equine cheek teeth, to explore the presence of instrumentation mishaps described in human dentistry and to explore anatomical complexities of the pulp cavity that often remain uninstrumented using microcomputed tomography (μCT).
Study Design: Ex-vivo randomised experiments.
BMC Pregnancy Childbirth
December 2024
Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Delivery mode has been linked to child health, e.g., allergic disease.
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