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Exercise Training and Probiotic Lacticaseibacillus rhamnosus GG Reduce Tetracycline-Induced Liver Oxidative Stress and Inflammation in Rats with Hepatic Steatosis.
Probiotics Antimicrob Proteins
October 2023
Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Lifestyle modification with regular exercise can improve metabolic diseases by reducing lipid profile and inflammation. Probiotics have been recently recommended not only for gastrointestinal diseases but also for metabolic and even degenerative diseases. Therefore, in the present study, the effect of high-intensity interval training (HIIT) and Lacticaseibacillus rhamnosus strain GG (LGG) as a probiotic on tetracycline-induced hepatic steatosis in an animal model was evaluated.
View Article and Find Full Text PDFTwo Antibiotics, Ampicillin and Tetracycline, Exert Different Effects in HT-29 Colorectal Adenocarcinoma Cells in Terms of Cell Viability and Migration Capacity.
Curr Oncol
July 2021
Faculty of Pharmacy, "Victor Babeș" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, RO-300041 Timisoara, Romania.
Antibiotics are considered the cornerstone of modern medicine; however, currently, antibiotic resistance has become a global health issue. Antibiotics also find new uses in the treatment of other pathologies as well as cancer. The present study aimed to verify the impact of tetracycline and ampicillin in a colorectal adenocarcinoma cell line, HT-29.
View Article and Find Full Text PDFEarly detection of metabolic changes in drug-induced steatosis using metabolomics approaches.
RSC Adv
November 2020
Department of Pharmaceutical and Biological Chemistry, University of London UK
Steatosis is the accumulation of triglycerides in hepatic cells wherein fats exceed 5% of the entire liver weight. Although steatotic liver damage is reversible due to the liver's regenerative capability, protracted damage often and typically leads to irreversible conditions such as cirrhosis and hepatocellular carcinoma (HCC). Therefore, early steatotic detection is critical for preventing progression to advanced liver diseases.
View Article and Find Full Text PDFRusty green stained temporal bone associated with exposure to tetracycline: an unusual presentation of black bone disease.
J Laryngol Otol
March 2015
Department of Head and Neck Surgery,David Geffen School of Medicine at UCLA, University of California,Los Angeles,USA.
Objective: To review the phenomenon and implications of temporal bone and craniofacial bone staining in the context of prolonged exposure to tetracycline antibiotic.
Methods: Case report and literature review.
Results: A 52-year-old male with a 5-year history of tetracycline use presented to undergo tympanomastoidectomy and was found to have an unusual rusty green pigmentation of the entire aspect of the exposed temporal bone.
Effects of tetracycline on developmental toxicity and molecular responses in zebrafish (Danio rerio) embryos.
Ecotoxicology
May 2015
State Key Laboratory of Estuarine and Coastal Research, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
The extensive use of pharmaceuticals has resulted in the intensive contamination of water bodies. Tetracycline is a type of antibiotic and its potential toxicity is causing environmental concern. The effects of developmental toxicity and the mechanisms of tetracycline on fish embryos are not well understood.
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