AI Article Synopsis
- Immune cell functions are influenced not only by pathogens but also by environmental factors like lysophospholipids (LPLs), which come from membrane glycerophospholipids.
- Studies show that LPLs can affect immune responses in both positive and negative ways through specific receptors known as G-protein-coupled receptors.
- The text highlights lysophosphatidic acid, lysophosphatidylserine (LysoPS), and lysophosphatidylinositol, with a specific focus on LysoPS and its recently discovered immunomodulatory effects.
Article Abstract
In addition to direct activation by pathogens and antigens, immune cell functions are further modulated by factors in their environment. Recent studies have revealed that lysophospholipids (LPL) derived from membrane glycerophospholipids are such environmental factors. They are produced by the action of various phospholipases and modulate immune responses positively or negatively via G-protein-coupled receptor-type receptors. These include lysophosphatidic acid, lysophosphatidylserine (LysoPS), and lysophosphatidylinositol. Here, we summarize what is known about the synthetic pathways, receptors, and immunomodulatory functions of these LPLs. Particular focus is given to LysoPS, which have recently been identified, and recent findings on their immunomodulatory actions are presented.
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| http://dx.doi.org/10.1111/imr.13204 | DOI Listing |
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