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| http://dx.doi.org/10.17269/s41997-023-00770-9 | DOI Listing |
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Inhibition of Kv1.3 channel restrains macrophage M2 polarization and ameliorates renal fibrosis via regulating STAT6 phosphorylation.
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NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening and Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences,Southern Medical University, Guangzhou 510515, China; Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), Ministry of Education, Guangzhou 510515, China. Electronic address:
Macrophages play crucial roles in regulating both homeostatic and inflammatory responses, with classical activated (M1) and alternatively activated (M2) subsets defined by the surrounding micro-environment. Renal fibrosis, developed from persistent inflammation, is worsened by M2 macrophages, yet the precise mechanisms underlying macrophage M2 polarization remain unclear. In this study, we investigated the role of Kv1.
View Article and Find Full Text PDFFasting-mimicking diet-enriched suppresses colorectal cancer by inducing memory CD8 T cells.
Gut
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Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
Background: Fasting-mimicking diet (FMD) boosts the antitumour immune response in patients with colorectal cancer (CRC). The gut microbiota is a key host immunity regulator, affecting physiological homeostasis and disease pathogenesis.
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Zonal Characteristics of Collagen Ultrastructure and Responses to Mechanical Loading in Articular Cartilage.
Acta Biomater
January 2025
Biomedical Engineering, College of Engineering, Mathematics and Physical Sciences, University of Exeter, UK. Electronic address:
The biomechanical properties of articular cartilage arise from a complex bioenvironment comprising hierarchically organised collagen networks within the extracellular matrix (ECM) that interact with the proteoglycan-rich interstitial fluid. This network features a depth-dependent fibril organisation across different zones. Understanding how collagen fibrils respond to external loading is key to elucidating the mechanisms behind lesion and managing degenerative conditions like osteoarthritis.
View Article and Find Full Text PDFReliable quantification of neural entrainment to rhythmic auditory stimulation: simulation and experimental validation.
J Neural Eng
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School of Biomedical Engineering, Southern Medical University, 1023 Shatai Road, Baiyun District, Guangzhou, Guangdong, 510515, CHINA.
Objective: Entrainment has been considered as a potential mechanism underlying the facilitatory effect of rhythmic neural stimulation on neurorehabilitation. The inconsistent effects of brain stimulation on neurorehabilitation found in the literature may be caused by the variability in neural entrainment. To dissect the underlying mechanisms and optimize brain stimulation for improved effectiveness, it is critical to reliably assess the occurrence and the strength of neural entrainment.
View Article and Find Full Text PDFA Spiropyran-Based Hydrogel Composite for Wearable Detectors to Monitor Visible Light Intensity to Prevent Myopia.
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Key Laboratory of Advanced Textile Materials & Manufacturing Technology, Ministry of Education, Zhejiang Sci-Tech University, 928 Second Avenue, 310018 Hangzhou, China.
A wearable detector to monitor visible light intensity is realized by the restrained photochromism of a hydrogel composite containing light-responsive spiropyran with hydroxyl groups (SPOH). When exposed to visible light, the SPOH experiences a ring-opening to a ring-closed transition accompanied by discoloration from red to yellow. Unlike in the solution, the photochromism/discoloration rate is strongly correlated to the cross-linking points.
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