Fe-catalyzed difunctionalization of aryl titanates via double C-H activation has been developed, where aryl titanates were arylated via C-H activation, followed by electrophilic trapping of the C-Ti bond. The C-H arylation should be promoted by a 1,2-Fe/Ti synergistic heterobimetallic arylene intermediate and represents an C-H ferration directed by a readily transformable C-Ti group. Common benzamides, esters, and nitriles function as arylating reagents, which involves another C-H activation directed by these functionalities.
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| http://dx.doi.org/10.1021/acs.orglett.3c00975 | DOI Listing |
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