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MSTN knockout enhances the production of MYOD1-mediated steak-type cultivated meat.
J Anim Sci Biotechnol
March 2025
Department of Theriogenology and Biotechnology, College of Veterinary Medicine and the Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul, 08826, Republic of Korea.
Background: As the global population increases, the demand for protein sources is expected to increase, driving the demand for cell-based cultivated meat. This study aimed to enhance the productivity of cultivated meat through optimization of the cell source and organization process.
Results: We engineered fibroblasts into myogenic cells via non-viral introduction of the MYOD1 gene, avoiding viral methods for safety.
Target Trial Emulation: A Concept Simply Explained.
J Clin Psychiatry
February 2025
Department of Psychiatry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India; Department of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neurosciences, Bangalore, India
Target trial emulation (TTE) is an observational, quasi-experimental research design that emulates a randomized clinical trial (RCT) structure within a large set of observational data; the "target trial" is a hypothetical RCT that would have ideally answered the research question. TTEs can address study objectives that, for ethical or logistic reasons, cannot easily be examined in RCTs. Advantages of TTEs over conventional approaches to observational data are that TTEs can reduce bias, improve the understanding of findings, and facilitate causal inference.
View Article and Find Full Text PDFGenetic Characterization of the Immortalized Human Nasopharyngeal Carcinoma Cell Line NPC/HK1.
Cancer Med
February 2025
Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), University Hospital Aachen, Aachen, Germany.
Background: Human nasopharyngeal carcinoma (NPC) cell lines are in vitro model systems that are widely available, easy to handle, and provide an unlimited supply of material. They also bypass ethical concerns associated with the use of primary human cells or tissue. However, many of these cell lines including 5-8F, 6-10B, CNE-1, CNE-2, HNE-1, HONE-1, SUNE1, SUNE2, and NPC-TW01 have been shown to be misidentified or cross-contaminated.
View Article and Find Full Text PDFStep-by-step causal analysis of EHRs to ground decision-making.
PLOS Digit Health
February 2025
Soda Team, Inria Saclay, Palaiseau, France.
Causal inference enables machine learning methods to estimate treatment effects of medical interventions from electronic health records (EHRs). The prevalence of such observational data and the difficulty for randomized controlled trials (RCT) to cover all population/treatment relationships make these methods increasingly attractive for studying causal effects. However, researchers should be wary of many pitfalls.
View Article and Find Full Text PDFDuration of aromatase inhibitor use and long-term cardiovascular risk in breast cancer survivors.
JNCI Cancer Spectr
January 2025
Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Background: There are limited data on duration of aromatase inhibitor (AI) and cardiovascular disease (CVD) risk in breast cancer (BC) survivors. We examined the risk of CVD and mortality associated with the duration of AI use in postmenopausal women with early stage hormone receptor-positive BC.
Methods: Postmenopausal women diagnosed with hormone receptor-positive BC (n = 5853) who used an AI were included.
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